FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W96160172> ?p ?o ?g. }

• W96160172 endingPage "113" @default.
• W96160172 startingPage "105" @default.
• W96160172 abstract "The INK4A and the INK4B genes map to chromosome 9p21, an area frequently deleted in bladder neoplasms. In addition to the p16 protein, the INK4A encodes for a second product, termed p19(ARF). We analyzed tissues from 121 patients with initial Ta and T1 tumors. Deletions of the INK4A gene were observed in 17 of 121 (14.1%) cases. Point mutations were identified in 2 of 64 (3.1%) tumors. The INK4A-exon 1beta and the INK4B gene were codeleted with INK4A in all of the homozygously deleted cases analyzed. The p16 promoter underwent de novo methylation in 7 of 47 (14.9%) evaluable cases. The p16-positive phenotype was observed in 18 of 56 (32%) evaluable cases. p16 negative phenotype correlated with deletion and methylation status. A statistically significant association between INK4A homozygous deletions and tumor size was observed (P = 0.003). Patients bearing tumors with INK4A homozygous deletions had a lower recurrence-free survival (P = 0.040) than those with wild type INK4A. In conclusion, deletions and methylation of the INK4A gene occur frequently in superficial bladder tumors. However, only those deletions that affect both the p16 and the p19(ARF), deregulating both the pRb and p53 pathways, correlated with clinicopathological parameters of worse prognosis." @default.
• W96160172 created "2016-06-24" @default.
• W96160172 creator A5012815468 @default.
• W96160172 creator A5030714353 @default.
• W96160172 creator A5046564499 @default.
• W96160172 creator A5066441919 @default.
• W96160172 creator A5066730612 @default.
• W96160172 creator A5075327765 @default.
• W96160172 creator A5080635562 @default.
• W96160172 creator A5080940311 @default.
• W96160172 creator A5091685985 @default.
• W96160172 date "1999-07-01" @default.
• W96160172 modified "2023-10-18" @default.
• W96160172 title "Deletions of the INK4A Gene in Superficial Bladder Tumors" @default.
• W96160172 cites W1499660750 @default.
• W96160172 cites W1503409848 @default.
• W96160172 cites W1510677006 @default.
• W96160172 cites W1518721136 @default.
• W96160172 cites W1583984382 @default.
• W96160172 cites W1586414137 @default.
• W96160172 cites W1601604261 @default.
• W96160172 cites W1602806521 @default.
• W96160172 cites W1777550737 @default.
• W96160172 cites W1967370147 @default.
• W96160172 cites W1971512164 @default.
• W96160172 cites W1973277018 @default.
• W96160172 cites W1973886069 @default.
• W96160172 cites W1973913393 @default.
• W96160172 cites W1977706798 @default.
• W96160172 cites W1983348452 @default.
• W96160172 cites W1983751803 @default.
• W96160172 cites W1994066190 @default.
• W96160172 cites W1994465394 @default.
• W96160172 cites W1997073961 @default.
• W96160172 cites W2003907692 @default.
• W96160172 cites W2010493387 @default.
• W96160172 cites W2038252730 @default.
• W96160172 cites W2039463309 @default.
• W96160172 cites W2049085719 @default.
• W96160172 cites W2066848701 @default.
• W96160172 cites W2069678419 @default.
• W96160172 cites W2074067954 @default.
• W96160172 cites W2077858999 @default.
• W96160172 cites W2084891010 @default.
• W96160172 cites W2109609879 @default.
• W96160172 cites W2122580718 @default.
• W96160172 cites W2123626443 @default.
• W96160172 cites W2143974840 @default.
• W96160172 cites W2147822352 @default.
• W96160172 cites W2152205227 @default.
• W96160172 cites W2157033538 @default.
• W96160172 cites W2169250920 @default.
• W96160172 cites W2262513754 @default.
• W96160172 cites W2419009425 @default.
• W96160172 cites W4245958676 @default.
• W96160172 cites W4293241248 @default.
• W96160172 doi "https://doi.org/10.1016/s0002-9440(10)65105-x" @default.
• W96160172 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1866649" @default.
• W96160172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10393843" @default.
• W96160172 hasPublicationYear "1999" @default.
• W96160172 type Work @default.
• W96160172 sameAs 96160172 @default.
• W96160172 citedByCount "121" @default.
• W96160172 countsByYear W961601722012 @default.
• W96160172 countsByYear W961601722013 @default.
• W96160172 countsByYear W961601722014 @default.
• W96160172 countsByYear W961601722015 @default.
• W96160172 countsByYear W961601722016 @default.
• W96160172 countsByYear W961601722017 @default.
• W96160172 countsByYear W961601722018 @default.
• W96160172 countsByYear W961601722020 @default.
• W96160172 countsByYear W961601722022 @default.
• W96160172 countsByYear W961601722023 @default.
• W96160172 crossrefType "journal-article" @default.
• W96160172 hasAuthorship W96160172A5012815468 @default.
• W96160172 hasAuthorship W96160172A5030714353 @default.
• W96160172 hasAuthorship W96160172A5046564499 @default.
• W96160172 hasAuthorship W96160172A5066441919 @default.
• W96160172 hasAuthorship W96160172A5066730612 @default.
• W96160172 hasAuthorship W96160172A5075327765 @default.
• W96160172 hasAuthorship W96160172A5080635562 @default.
• W96160172 hasAuthorship W96160172A5080940311 @default.
• W96160172 hasAuthorship W96160172A5091685985 @default.
• W96160172 hasBestOaLocation W961601722 @default.
• W96160172 hasConcept C104317684 @default.
• W96160172 hasConcept C127716648 @default.
• W96160172 hasConcept C142724271 @default.
• W96160172 hasConcept C153911025 @default.
• W96160172 hasConcept C176944494 @default.
• W96160172 hasConcept C2778264664 @default.
• W96160172 hasConcept C33288867 @default.
• W96160172 hasConcept C36823959 @default.
• W96160172 hasConcept C501734568 @default.
• W96160172 hasConcept C502942594 @default.
• W96160172 hasConcept C54355233 @default.
• W96160172 hasConcept C555283112 @default.
• W96160172 hasConcept C71924100 @default.
• W96160172 hasConcept C86803240 @default.

• next