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- W96184983 abstract "In the diabetic eye, the increased accumulation of sorbitol in the retina has been implicated in the pathogenesis of diabetic retinopathy (DR). Neurodegeneration is an important component of DR as demonstrated by increased neural apoptosis in the retina during experimental and human diabetes. Insulin receptor (IR) activation has been shown to rescue retinal neurons from apoptosis through a phosphoinositide 3-kinase and protein kinase B (Akt) survival cascade. In this study, we examined the IR signaling in sorbitol-induced hyperosmotic stressed retinas." @default.
- W96184983 created "2016-06-24" @default.
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- W96184983 date "2009-01-01" @default.
- W96184983 modified "2023-09-24" @default.
- W96184983 title "Chapter 20 Retinal Insulin Receptor Signaling In Hyperosmotic Stress" @default.
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- W96184983 doi "https://doi.org/10.1016/s0083-6729(08)00620-1" @default.
- W96184983 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2670484" @default.
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