Matches in SemOpenAlex for { <https://semopenalex.org/work/W962056995> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W962056995 abstract "MILLIONS OF PEOPLE all over the world suffer from parasitic diseases, such as African sleeping sickness and Chagas’ disease, which, particularly in the less developed countries, lead to sickness, deformities and ultimately death. Additionally, with global warming there are growing concerns about the threat from insect-transmitted diseases increasing as vectors move into new areas, including southern Europe and the southern states of the US. Most of the conventional drug therapies that are currently used to treat these parasitic diseases have unknown drug targets. Thus, research is underway to build a deeper understanding of the differences between the parasitic metabolism and that of humans. At the University of St Andrews in Scotland a group of researchers is using multidisciplinary approaches, incorporating chemistry, biochemistry and molecular parasitology, to investigate phospholipid and glycolipid metabolism in the hopes of uncovering some of the parasite’s secrets.Their ultimate aim is the discovery of new therapeutic agents for parasitic diseases. To achieve this they are focusing on uncovering the lipid metabolic pathways that are present in parasites. Dr Terry Smith, a Reader in the University’s Schools of Biology and Chemistry and the man in charge of this latest research, says that a biosynthetic step which is unique to the parasite, is often favoured as a drug therapy which targets this process, and is likely to have no effect on the patient. However, through their investigations they have demonstrated that the parasite is potentially vulnerable to drug intervention because of the metabolic route and steps that they are missing. “In other words, we can inhibit the only route by which parasites make their essential choline containing phospholipids, whereas we as humans have redundant routes or processes by which to make choline-containing phospholipids,” Smith adds." @default.
- W962056995 created "2016-06-24" @default.
- W962056995 creator A5005777264 @default.
- W962056995 creator A5017202324 @default.
- W962056995 creator A5080714525 @default.
- W962056995 creator A5086350788 @default.
- W962056995 date "2012-10-01" @default.
- W962056995 modified "2023-09-25" @default.
- W962056995 title "Targeting new drugs with choline metabolism." @default.
- W962056995 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3892147" @default.
- W962056995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24443701" @default.
- W962056995 hasPublicationYear "2012" @default.
- W962056995 type Work @default.
- W962056995 sameAs 962056995 @default.
- W962056995 citedByCount "0" @default.
- W962056995 crossrefType "journal-article" @default.
- W962056995 hasAuthorship W962056995A5005777264 @default.
- W962056995 hasAuthorship W962056995A5017202324 @default.
- W962056995 hasAuthorship W962056995A5080714525 @default.
- W962056995 hasAuthorship W962056995A5086350788 @default.
- W962056995 hasConcept C118552586 @default.
- W962056995 hasConcept C142724271 @default.
- W962056995 hasConcept C2779134260 @default.
- W962056995 hasConcept C2780035454 @default.
- W962056995 hasConcept C2780301010 @default.
- W962056995 hasConcept C2780665704 @default.
- W962056995 hasConcept C60644358 @default.
- W962056995 hasConcept C71924100 @default.
- W962056995 hasConcept C74187038 @default.
- W962056995 hasConcept C86803240 @default.
- W962056995 hasConcept C98274493 @default.
- W962056995 hasConceptScore W962056995C118552586 @default.
- W962056995 hasConceptScore W962056995C142724271 @default.
- W962056995 hasConceptScore W962056995C2779134260 @default.
- W962056995 hasConceptScore W962056995C2780035454 @default.
- W962056995 hasConceptScore W962056995C2780301010 @default.
- W962056995 hasConceptScore W962056995C2780665704 @default.
- W962056995 hasConceptScore W962056995C60644358 @default.
- W962056995 hasConceptScore W962056995C71924100 @default.
- W962056995 hasConceptScore W962056995C74187038 @default.
- W962056995 hasConceptScore W962056995C86803240 @default.
- W962056995 hasConceptScore W962056995C98274493 @default.
- W962056995 hasLocation W9620569951 @default.
- W962056995 hasOpenAccess W962056995 @default.
- W962056995 hasPrimaryLocation W9620569951 @default.
- W962056995 hasRelatedWork W1504508182 @default.
- W962056995 hasRelatedWork W1826272610 @default.
- W962056995 hasRelatedWork W1967924938 @default.
- W962056995 hasRelatedWork W1969972719 @default.
- W962056995 hasRelatedWork W1972679617 @default.
- W962056995 hasRelatedWork W1975445946 @default.
- W962056995 hasRelatedWork W1985030551 @default.
- W962056995 hasRelatedWork W2005171353 @default.
- W962056995 hasRelatedWork W2023852942 @default.
- W962056995 hasRelatedWork W2029327430 @default.
- W962056995 hasRelatedWork W2031507955 @default.
- W962056995 hasRelatedWork W2037888630 @default.
- W962056995 hasRelatedWork W2040071674 @default.
- W962056995 hasRelatedWork W2046845986 @default.
- W962056995 hasRelatedWork W2051979077 @default.
- W962056995 hasRelatedWork W2173363282 @default.
- W962056995 hasRelatedWork W2201937145 @default.
- W962056995 hasRelatedWork W2343557959 @default.
- W962056995 hasRelatedWork W2989812189 @default.
- W962056995 hasRelatedWork W766167974 @default.
- W962056995 isParatext "false" @default.
- W962056995 isRetracted "false" @default.
- W962056995 magId "962056995" @default.
- W962056995 workType "article" @default.