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- W962323912 abstract "Objective To study the children immune function impacts caused by drinking water with high level arsenic.Methods One hundred and ninty-four pupils were selected as the study subjects,samples of the household drinking water were sampled and the samples of the fasting morning urine were collected,and the water and urinary arsenic concentrations were determined in 2006.The subjects were divided as control group(concentration of arsenic in water 0.05 mg/L)and exposure group(concentration of arsenic in water ≥0.1mg/L) according to the water arsenic concentration and the T-lymphocyte subsets,immunoglobulin IgG,IgM,IgA and interleukin-2(IL-2) were measured in the two groups'children aged over 9 years.The family general information,drinking water sources,parents'health and occupational exposure situations by questionnaire were investigated.Results In control and exposure group,the urinary arsenic medians were 0.02 mg/L and 0.12 mg/L respectively,urinary arsenic and water arsenic content correlated significantly.The mean percentages of T lymphocytes(CD3+),CD4+,CD8+ subsets and the mean of CD4+/CD8+ in exposure group were lower than those in control group.The mean percentages of CD4+ subsets and CD4+/CD8+ in exposure group were significant lower than those in control group(P0.05).The percentage of boys'T lymphocytes CD4+ in exposure group was significant lower than that in control group(P0.05),and the percentage of girls'T lymphocytes CD4+ and the mean of CD4+/CD8+ in exposure group were lower than those in control group.The blood serum IgG content of the children in exposure group was higher,the IgM content was lower compared with the control group(P0.05).Conclusion Drinking the water with high arsenic concentration over 0.1 mg/L can cause adverse impacts to children immune function.Children's peripheral blood T lymphocyte subset is one of the most sensitive health effective indicators to water arsenic exposure." @default.
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- W962323912 date "2009-01-01" @default.
- W962323912 modified "2023-09-23" @default.
- W962323912 title "Effects of arsenic exposure through drinking water on immune function of children." @default.
- W962323912 hasPublicationYear "2009" @default.
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