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- W962419645 abstract "This chapter describes the detection and quantitation of circulating immune complexes by the C1q-protein a binding assay (C1q-PABA). The assay makes use of the solid-phase Clq for the binding of IC or aggregated IgG and subsequent indication of the IC bound by 123I-labeled protein A. In Clq-PABA, iodinated staphylococcal protein A is used as the indicator molecule for the detection of Clq-bound IC or aggregated IgG. The final C1 and Clq preparations are tested for purity, by double immunodiffusion and crossed immunoelectrophoresis, and for the biological activity in a latex globulin reagent agglutination assay. The purification factor for C1 is approximately 100 and for the Clq preparation is 800. The demonstration of IC in cerebrospinal fluid (CSF), by C1q-PABA, is described in the chapter, by a study of IC occurrence in CSF, from 14 patients with multiple sclerosis and 30 patients with other neurological diseases. The binding of C1q to antigen-antibody complexes is reported to be enhanced when the ionic strength of the milieu is reduced, suggesting that the bonds primarily involved in the reaction are ionic in nature." @default.
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- W962419645 date "1981-01-01" @default.
- W962419645 modified "2023-09-25" @default.
- W962419645 title "[38] Detection and quantitation of circulating immune complexes by the C1q-Protein A binding assay (C1q-PABA)" @default.
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- W962419645 doi "https://doi.org/10.1016/0076-6879(81)74040-0" @default.
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