FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W962473119> ?p ?o ?g. }

• W962473119 endingPage "46" @default.
• W962473119 startingPage "39" @default.
• W962473119 abstract "Abstract Cystathionine beta synthase (CBS) deficiency is a recessive inborn error of metabolism characterized by elevated serum total homocysteine (tHcy). Betaine supplementation, which can lower tHcy by stimulating homocysteine remethylation to methionine, is often given to CBS deficient patients in combination with other treatments such as methionine restriction and supplemental B‐vitamins. However, the effectiveness of betaine supplementation by itself in the treatment of CBS deficiency has not been well explored. Here, we have examined the effect of a betaine supplemented diet on the Tg‐I278T Cbs −/− mouse model of CBS deficiency and compared its effectiveness to our previously published data using a methionine restricted diet. Tg‐I278T Cbs −/− mice on betaine, from the time of weaning until for 240 days of age, had a 40 % decrease in mean tHcy level and a 137 % increase in serum methionine levels. Betaine‐treated Tg‐I278T Cbs −/− mice also exhibited increased levels of betaine‐dependent homocysteine methyl transferase (BHMT), increased levels of the lipogenic enzyme stearoyl‐coenzyme A desaturase (SCD‐1), and increased lipid droplet accumulation in the liver. Betaine supplementation largely reversed the hair loss phenotype in Tg‐I278T Cbs −/− animals, but was far less effective than methionine restriction in reversing the weight‐loss, fat‐loss, and osteoporosis phenotypes. Surprisingly, betaine supplementation had several negative effects in control Tg‐I278T Cbs +/− mice including decreased weight gain, lean mass, and bone mineral density. Our findings indicate that while betaine supplementation does have some beneficial effects, it is not as effective as methionine restriction for reversing the phenotypes associated with severe CBS deficiency in mice." @default.
• W962473119 created "2016-06-24" @default.
• W962473119 creator A5011552984 @default.
• W962473119 creator A5051979437 @default.
• W962473119 creator A5086746753 @default.
• W962473119 date "2015-08-01" @default.
• W962473119 modified "2023-09-25" @default.
• W962473119 title "Betaine supplementation is less effective than methionine restriction in correcting phenotypes of CBS deficient mice" @default.
• W962473119 cites W1559869836 @default.
• W962473119 cites W1588957423 @default.
• W962473119 cites W1939441056 @default.
• W962473119 cites W1971061691 @default.
• W962473119 cites W1978748829 @default.
• W962473119 cites W1988901034 @default.
• W962473119 cites W2001673235 @default.
• W962473119 cites W2003462478 @default.
• W962473119 cites W2011550644 @default.
• W962473119 cites W2017144271 @default.
• W962473119 cites W2027396261 @default.
• W962473119 cites W2037027214 @default.
• W962473119 cites W2038017204 @default.
• W962473119 cites W2053859983 @default.
• W962473119 cites W2061991503 @default.
• W962473119 cites W2063086702 @default.
• W962473119 cites W2073756056 @default.
• W962473119 cites W2078369761 @default.
• W962473119 cites W2094115156 @default.
• W962473119 cites W2117900461 @default.
• W962473119 cites W2121836743 @default.
• W962473119 cites W2133377749 @default.
• W962473119 cites W2138439179 @default.
• W962473119 cites W2148010796 @default.
• W962473119 cites W2170539205 @default.
• W962473119 cites W311377574 @default.
• W962473119 cites W4205114224 @default.
• W962473119 doi "https://doi.org/10.1007/s10545-015-9883-z" @default.
• W962473119 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4784539" @default.
• W962473119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26231230" @default.
• W962473119 hasPublicationYear "2015" @default.
• W962473119 type Work @default.
• W962473119 sameAs 962473119 @default.
• W962473119 citedByCount "18" @default.
• W962473119 countsByYear W9624731192015 @default.
• W962473119 countsByYear W9624731192016 @default.
• W962473119 countsByYear W9624731192017 @default.
• W962473119 countsByYear W9624731192018 @default.
• W962473119 countsByYear W9624731192019 @default.
• W962473119 countsByYear W9624731192020 @default.
• W962473119 countsByYear W9624731192021 @default.
• W962473119 countsByYear W9624731192022 @default.
• W962473119 countsByYear W9624731192023 @default.
• W962473119 crossrefType "journal-article" @default.
• W962473119 hasAuthorship W962473119A5011552984 @default.
• W962473119 hasAuthorship W962473119A5051979437 @default.
• W962473119 hasAuthorship W962473119A5086746753 @default.
• W962473119 hasBestOaLocation W9624731192 @default.
• W962473119 hasConcept C126322002 @default.
• W962473119 hasConcept C134018914 @default.
• W962473119 hasConcept C16525657 @default.
• W962473119 hasConcept C185592680 @default.
• W962473119 hasConcept C2777090595 @default.
• W962473119 hasConcept C2777248517 @default.
• W962473119 hasConcept C2779375456 @default.
• W962473119 hasConcept C2780912031 @default.
• W962473119 hasConcept C515207424 @default.
• W962473119 hasConcept C55493867 @default.
• W962473119 hasConcept C71924100 @default.
• W962473119 hasConcept C80315684 @default.
• W962473119 hasConcept C86803240 @default.
• W962473119 hasConceptScore W962473119C126322002 @default.
• W962473119 hasConceptScore W962473119C134018914 @default.
• W962473119 hasConceptScore W962473119C16525657 @default.
• W962473119 hasConceptScore W962473119C185592680 @default.
• W962473119 hasConceptScore W962473119C2777090595 @default.
• W962473119 hasConceptScore W962473119C2777248517 @default.
• W962473119 hasConceptScore W962473119C2779375456 @default.
• W962473119 hasConceptScore W962473119C2780912031 @default.
• W962473119 hasConceptScore W962473119C515207424 @default.
• W962473119 hasConceptScore W962473119C55493867 @default.
• W962473119 hasConceptScore W962473119C71924100 @default.
• W962473119 hasConceptScore W962473119C80315684 @default.
• W962473119 hasConceptScore W962473119C86803240 @default.
• W962473119 hasIssue "1" @default.
• W962473119 hasLocation W9624731191 @default.
• W962473119 hasLocation W9624731192 @default.
• W962473119 hasLocation W9624731193 @default.
• W962473119 hasLocation W9624731194 @default.
• W962473119 hasOpenAccess W962473119 @default.
• W962473119 hasPrimaryLocation W9624731191 @default.
• W962473119 hasRelatedWork W1964318101 @default.
• W962473119 hasRelatedWork W1978748829 @default.
• W962473119 hasRelatedWork W2031280790 @default.
• W962473119 hasRelatedWork W2037027214 @default.
• W962473119 hasRelatedWork W2075983709 @default.
• W962473119 hasRelatedWork W2106546044 @default.
• W962473119 hasRelatedWork W2109863803 @default.
• W962473119 hasRelatedWork W3200748889 @default.
• W962473119 hasRelatedWork W962473119 @default.

• next