FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W96258532> ?p ?o ?g. }

• W96258532 endingPage "97" @default.
• W96258532 startingPage "181" @default.
• W96258532 abstract "The electrocardiogram shows a sequence of cardiac electrical events generated by individual electrical currents generated mainly by sodium (Na+), potassium (K+) and calcium (Ca++) ions transiting via specialized transport pathways, such as ion channels, inserted in the membranes of excitable cardiac cells. Na+ and Ca++, entering the cells, are messengers of activating, inward, depolarizing currents (INa, ICa), generating the QRS wave of the electrocardiogram, whereas K+, leaving the cells, carries outward repolarizing currents (e.g. Ito, IKr, IKs and IK1), generating the T wave of the electrocardiogram, which drives the cell to a rest condition. Therefore, a significantly prolonged repolarization process results in a prolonged QT interval which can initiate ectopic cardiac beats that may evolve into a potentially lethal ventricular tachyarrhythmia, called torsades de pointes. This implies that the measurement of QT interval, appropriately corrected (QTc) for heart rate values by applying available algorithms, is a current tool of diagnostic investigation to reveal abnormalities of the cardiac repolarisation process. Numerous non cardiovascular drugs in general clinical use (psychotropics, prokinetics, antimalarials, antibiotics, antihistamines, etc.) can prolong QT interval, often by a mechanism not necessary for their therapeutic effects, which is a reduction of the potassium current IKr conveyed by the HERG channel. The torsadogenic potential of these drugs can be facilitated by factors (female gender, bradycardia, electrolyte imbalances, cardiac diseases, simultaneous use of multiple drugs prolonging QT interval, etc.) known to have the propensity to reduce the redundant cardiac repolarization reserve, characterizing the healthy myocardium. Presently, drug candidates are routinely subjected to preclinical and clinical examination for cardiac safety, a property required by health authorities for any new medicine before allowing marketing authorization. Finally, before prescribing a medicinal product prolonging QT interval, a physician should carefully evaluate not only the disease he wants to treat but also the availability of equally effective, alternative drugs. The golden rule, to which such a prescription has always to abide, requires that the beneficial effects expected from a therapy should for each treated patient outweigh any possible adverse consequence, particularly when the latter one could be of lethal nature." @default.
• W96258532 created "2016-06-24" @default.
• W96258532 creator A5008782167 @default.
• W96258532 creator A5048743169 @default.
• W96258532 date "2002-06-01" @default.
• W96258532 modified "2023-09-23" @default.
• W96258532 title "[Ventricular arrhythmias. A potential risk associated with the use of non-cardiovascular drugs prolonging the QT interval]." @default.
• W96258532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12094149" @default.
• W96258532 hasPublicationYear "2002" @default.
• W96258532 type Work @default.
• W96258532 sameAs 96258532 @default.
• W96258532 citedByCount "2" @default.
• W96258532 countsByYear W962585322019 @default.
• W96258532 crossrefType "journal-article" @default.
• W96258532 hasAuthorship W96258532A5008782167 @default.
• W96258532 hasAuthorship W96258532A5048743169 @default.
• W96258532 hasConcept C111773187 @default.
• W96258532 hasConcept C118441451 @default.
• W96258532 hasConcept C126322002 @default.
• W96258532 hasConcept C146403970 @default.
• W96258532 hasConcept C155730078 @default.
• W96258532 hasConcept C164705383 @default.
• W96258532 hasConcept C185263204 @default.
• W96258532 hasConcept C2775935837 @default.
• W96258532 hasConcept C2777008848 @default.
• W96258532 hasConcept C2777495988 @default.
• W96258532 hasConcept C2777953023 @default.
• W96258532 hasConcept C2779161974 @default.
• W96258532 hasConcept C2779362680 @default.
• W96258532 hasConcept C2779578097 @default.
• W96258532 hasConcept C2779703243 @default.
• W96258532 hasConcept C2780040984 @default.
• W96258532 hasConcept C2780339425 @default.
• W96258532 hasConcept C2780486423 @default.
• W96258532 hasConcept C2988455589 @default.
• W96258532 hasConcept C71924100 @default.
• W96258532 hasConcept C79743260 @default.
• W96258532 hasConcept C83743174 @default.
• W96258532 hasConcept C84393581 @default.
• W96258532 hasConceptScore W96258532C111773187 @default.
• W96258532 hasConceptScore W96258532C118441451 @default.
• W96258532 hasConceptScore W96258532C126322002 @default.
• W96258532 hasConceptScore W96258532C146403970 @default.
• W96258532 hasConceptScore W96258532C155730078 @default.
• W96258532 hasConceptScore W96258532C164705383 @default.
• W96258532 hasConceptScore W96258532C185263204 @default.
• W96258532 hasConceptScore W96258532C2775935837 @default.
• W96258532 hasConceptScore W96258532C2777008848 @default.
• W96258532 hasConceptScore W96258532C2777495988 @default.
• W96258532 hasConceptScore W96258532C2777953023 @default.
• W96258532 hasConceptScore W96258532C2779161974 @default.
• W96258532 hasConceptScore W96258532C2779362680 @default.
• W96258532 hasConceptScore W96258532C2779578097 @default.
• W96258532 hasConceptScore W96258532C2779703243 @default.
• W96258532 hasConceptScore W96258532C2780040984 @default.
• W96258532 hasConceptScore W96258532C2780339425 @default.
• W96258532 hasConceptScore W96258532C2780486423 @default.
• W96258532 hasConceptScore W96258532C2988455589 @default.
• W96258532 hasConceptScore W96258532C71924100 @default.
• W96258532 hasConceptScore W96258532C79743260 @default.
• W96258532 hasConceptScore W96258532C83743174 @default.
• W96258532 hasConceptScore W96258532C84393581 @default.
• W96258532 hasIssue "3" @default.
• W96258532 hasLocation W962585321 @default.
• W96258532 hasOpenAccess W96258532 @default.
• W96258532 hasPrimaryLocation W962585321 @default.
• W96258532 hasRelatedWork W1971087918 @default.
• W96258532 hasRelatedWork W1990637512 @default.
• W96258532 hasRelatedWork W1998887747 @default.
• W96258532 hasRelatedWork W2034211254 @default.
• W96258532 hasRelatedWork W2104364676 @default.
• W96258532 hasRelatedWork W2131472696 @default.
• W96258532 hasRelatedWork W2150527882 @default.
• W96258532 hasRelatedWork W3196791221 @default.
• W96258532 hasRelatedWork W4211247258 @default.
• W96258532 hasRelatedWork W96258532 @default.
• W96258532 hasVolume "93" @default.
• W96258532 isParatext "false" @default.
• W96258532 isRetracted "false" @default.
• W96258532 magId "96258532" @default.
• W96258532 workType "article" @default.