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- W962685969 abstract "This chapter describes some of the better-understood systems, primarily in bacteria and yeast, that exhibit regulation of modification enzyme activity or gene expression. It attempts to bring out the common themes about regulation that are emerging from ongoing studies of the modification process. The efficiency of nonsense codon suppression has been exploited to analyze the effects of tRNA modification on decoding and codon context in bacteria and eukaryotes. New genetic approaches combined with high-pressure liquid chromatography (HPLC) screening and reverse genetics will likely lead to the identification of the remaining tRNA and rRNA modification genes in bacteria and yeast. A recent determination by quantitative Western immunoblotting showed that the MiaA (i6A37) prenyltransferase is also a moderately abundant enzyme at about 650 monomers per cell (≈ 1 μM) in bacteria growing exponentially in enriched minimal-glucose medium. MiaA may need to be present in comparatively high cellular amounts, because its activity is strongly competitively inhibited for its prenyl substrate, dimethylallyl diphosphate (alternatively called Δ2-isopentenyl pyrophosphate), by nucleotide di- and triphosphates. The genes whose expression is affected by these undermodifications need to be identified by two-dimensional gel analyses or genetic methods using random lacZ fusions. After these targets are identified, it will be possible to access whether the magnitude of the effects of undermodification on gene expression is sufficiently large to readily indicate physiological significance." @default.
- W962685969 created "2016-06-24" @default.
- W962685969 creator A5006090738 @default.
- W962685969 date "2014-04-30" @default.
- W962685969 modified "2023-09-27" @default.
- W962685969 title "Genetics and Regulation of Base Modification in the tRNA and rRNA of Prokaryotes and Eukaryotes" @default.
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