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- W96298209 abstract "Abstract Interleukin (IL)-27 is a member of the IL-6/IL-12 family and activates both signal transducer and activator of transcription (STAT)1 and STAT3 through its receptor, which consists of WSX-1 and gp130. We previously demonstrated that IL-27 has potent antitumor activities, which are mediated through CD8+ T cells, natural killer (NK) cells or its anti-angiogenic activity. Here, we demonstrate that IL-27 also possesses a direct anti-proliferative activity on melanoma cells. Although WSX-1 expression was hardly detected in parental mouse melanoma B16F10 cells, IL-27 activated STAT1 and STAT3 and up-regulated major histocompatibility complex (MHC) class I in B16F10 transfectants expressing wild-type WSX-1. In contrast, IL-27 failed to activate STAT1 and up-regulate MHC class I in those expressing mutant WSX-1, in which the putative STAT1-binding Tyr-609 of the cytoplasmic region was replaced by Phe. IL-27 greatly inhibited the cell growth of transfectants expressing wild-type WSX-1 but not the mutant, and induced apoptosis and G1 arrest. Several human melanoma cells were also reveled to express both IL-27 receptor subunits, and activation of STAT1 and STAT3 and growth inhibition by IL-27 were observed. These results suggest that IL-27 has an anti-proliferative activity on mouse and human melanoma cells through WSX-1/STAT1." @default.
- W96298209 created "2016-06-24" @default.
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- W96298209 date "2007-04-01" @default.
- W96298209 modified "2023-09-23" @default.
- W96298209 title "Anti-proliferative effect of interleukin-27 on melanoma cells (48.23)" @default.
- W96298209 doi "https://doi.org/10.4049/jimmunol.178.supp.48.23" @default.
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