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- W963018 abstract "Age-related macular degeneration (AMD) is a multifactorial disease involving genetic and environmental factors. Most of the genetic factors identified so far involve the nuclear genome. Recently, two studies in North America and Australia reported an association between advanced AMD and the mitochondrial T2 haplogroup. Our purpose was to assess this association in a large French population.This case control study included 1,224 patients with neovascular AMD and 559 controls with normal fundus. Mitochondrial DNA polymorphisms at and around nucleotides 4917, 11,812, and 14,233 were determined using PCR amplification and direct sequencing of mitochondrial DNA.No association was found between the mitochondrial T2 haplogroup and neovascular AMD in the French population: 94/1,152 patients with neovascular AMD had the T2 haplogroup (8.2%) versus 34/482 controls (7.1%; odds ratio=0.9 [0.5-1.5], p=0.66).An association between AMD and the T2 haplogroup, previously described in North American and Australian populations, was not confirmed in a large French population." @default.
- W963018 created "2016-06-24" @default.
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- W963018 date "2013-01-01" @default.
- W963018 modified "2023-10-17" @default.
- W963018 title "Genetic association study of mitochondrial polymorphisms in neovascular age-related macular degeneration." @default.
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