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- W963272803 abstract "293 Primary effusion lymphoma (PEL) is a fatal lymphoma associated with Kaposi’s sarcoma herpesvirus (KSHV) infection that typically presents as a malignant effusion in body cavities and later disseminates. There is a need for new therapies for PEL as most patients rapidly succumb in spite of high-dose chemotherapy. We developed a murine model of PEL that closely mimics the human disease to evaluate the anti-tumor activities of Rapamycin, which targets mTOR (mammalian target of Rapamycin), an effector of cell-signaling pathways often deregulated in cancer. We found that Rapamycin markedly delayed PEL development, significantly reduced ascites accumulation (P=0.009), prevented solid tumor formation, and significantly extended mouse survival (P" @default.
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- W963272803 date "2008-05-01" @default.
- W963272803 modified "2023-09-24" @default.
- W963272803 title "Use of Rapamycin to inhibit VEGF for the treatment of primary effusion lymphoma" @default.
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