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- W963400071 abstract "Both intrinsic (genetic) and extrinsic (environmental) factors play important roles in cancer pathogenesis.Mutations in three major classes of genes (oncogenes, tumor suppressor genes, and DNA mismatch repair genes) predispose individuals to malignancy.Hereditary cancer accounts for only 5–10% of the total cancer burden in humans.Genetic testing is only currently available for familial cancer syndromes.Over 30 familial cancer syndrome genes have been identified and genetic tests are available for all of them.Effective prophylactic treatments are available only for carriers of some of these familial cancer genes.Ethical and legal issues are also important considerations in the application of genetic testing for cancer screening. Cancer gene carriers will have a potential threat of decreased health and life insurability and compromised employability." @default.
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- W963400071 date "2002-01-01" @default.
- W963400071 modified "2023-09-23" @default.
- W963400071 title "Molecular Genetics and Cancer Screening" @default.
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- W963400071 doi "https://doi.org/10.1007/978-1-59259-191-6_18" @default.
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