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- W963757103 abstract "Publisher Summary This chapter describes the properties of the eukaryotic DNA kinases and compares them with those of the RNA kinase and of the polynucleotide kinase. The most thoroughly characterized DNA kinase is the activity from nuclei of rat liver. DNA kinase essentially catalyzes the reversible transfer of a phosphate group between a nucleoside triphosphate and the 5′-hydroxyl moiety at the terminus of a DNA chain. The reaction catalyzed by the rat liver DNA kinase proceeds by a sequential mechanism (without involvement of a covalently linked enzyme-substrate complex). The DNA kinase of rat liver is effectively used to introduce labeled 5′-phosphate groups at single-strand breaks in duplex DNA. Such labeled DNA can be used to assay DNA ligase activity. The distribution of the DNA kinase is consistent with a role in DNA repair processes. The activity is confined to the cell nucleus in rat liver. DNA kinases from rat liver and calf thymus phosphorylate DNA termini at a much greater rate than RNA termini, although the calf thymus preparations show some activity on RNA termini. The demonstration of the RNA kinase emphasizes a need for caution in evaluating the low levels of activity on RNA that were shown by partially purified preparations of DNA kinase from calf thymus." @default.
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- W963757103 date "1981-01-01" @default.
- W963757103 modified "2023-09-27" @default.
- W963757103 title "17 Eukaryotic DNA Kinases" @default.
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- W963757103 doi "https://doi.org/10.1016/s1874-6047(08)60343-1" @default.
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