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• W963887890 abstract "Research Article1 October 1993free access Receptor protein tyrosine phosphatase alpha activates pp60c-src and is involved in neuronal differentiation. J. den Hertog J. den Hertog Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht. Search for more papers by this author C.E. Pals C.E. Pals Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht. Search for more papers by this author M.P. Peppelenbosch M.P. Peppelenbosch Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht. Search for more papers by this author L.G. Tertoolen L.G. Tertoolen Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht. Search for more papers by this author S.W. de Laat S.W. de Laat Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht. Search for more papers by this author W. Kruijer W. Kruijer Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht. Search for more papers by this author J. den Hertog J. den Hertog Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht. Search for more papers by this author C.E. Pals C.E. Pals Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht. Search for more papers by this author M.P. Peppelenbosch M.P. Peppelenbosch Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht. Search for more papers by this author L.G. Tertoolen L.G. Tertoolen Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht. Search for more papers by this author S.W. de Laat S.W. de Laat Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht. Search for more papers by this author W. Kruijer W. Kruijer Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht. Search for more papers by this author Author Information J. Hertog1, C.E. Pals1, M.P. Peppelenbosch1, L.G. Tertoolen1, S.W. Laat1 and W. Kruijer1 1Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht. The EMBO Journal (1993)12:3789-3798https://doi.org/10.1002/j.1460-2075.1993.tb06057.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Here we report that protein tyrosine phosphatases (PTPases), like their enzymatic counterpart the protein tyrosine kinases, can play an important role in cell differentiation. Expression of the transmembrane PTPase receptor protein tyrosine phosphatase alpha (RPTP alpha) is transiently enhanced during neuronal differentiation of embryonal carcinoma (EC) and neuroblastoma cells. Retinoic acid induces wild type P19 cells to differentiate into endoderm- and mesoderm-like cells. By contrast, retinoic acid treatment leads to neuronal differentiation of P19 cells, ectopically expressing functional RPTP alpha, as illustrated by their ability to generate action potentials. Endogenous pp60c-src kinase activity is enhanced in the RPTP alpha-transfected cells, which may be due to direct dephosphorylation of the regulatory Tyr residue at position 527 in pp60c-src by RPTP alpha. Our results demonstrate that RPTP alpha is involved in neuronal differentiation and imply a role for pp60c-src in the differentiation process. Previous ArticleNext Article Volume 12Issue 101 October 1993In this issue RelatedDetailsLoading ..." @default.
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• W963887890 date "1993-10-01" @default.
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• W963887890 title "Receptor protein tyrosine phosphatase alpha activates pp60c-src and is involved in neuronal differentiation." @default.
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• W963887890 doi "https://doi.org/10.1002/j.1460-2075.1993.tb06057.x" @default.
• W963887890 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/413662" @default.
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