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• W963922907 endingPage "394" @default.
• W963922907 startingPage "357" @default.
• W963922907 abstract "In the nervous system, voltage-gated Na+ and K+ channels effect the upstroke and repolarizing phases, respectively, of the action potential. Cells of the immune system do not generate action potentials. Depolarization that induces Ca2+ signals in electrically excitable nerve and muscle cells inhibits Ca2+ signaling and the subsequent cascade of cell-activation events in lymphocytes. Several distinct types of voltage-gated and second-messenger-operated K+ and C1− channels exist in T and B lymphocytes, including channel types also expressed in the nervous system, as well as novel channels not described in other cell types. In electrically inexcitable cells, ion channels mediate cellular functions, involving intracellular biochemical signaling. The presence of K+ channels is apparently required for several basic functions in T lymphocytes. There is diversity of ion channels within cells of the hematopoietic lineage. In T lymphocytes, at least eight distinct types of K+, C1−, and Ca2+ channels have been characterized. Investigators have also recorded from bone marrow cells, thymocytes, B lymphocytes, monocytes, macrophages, neutrophils, red blood cells, eosinophils, and platelets, as well as numerous related cell lines, including a human T-leukemia line, a mouse T-lymphoma line (S49), a variety of antibody-secreting hybridomas, and a mast-cell line derived from a rat basophilic leukemia (RBL). These studies have revealed transient or T-type voltage-gated Ca2+channels (hybridomas), inward-rectifying K+ channels (macrophages, RBL cells), large-conductance Ca2+-activated K+ channels (macrophages), Ca2+-activated C1− current (mast cells), and G-protein-activated K+ channels (RBL cells). In this chapter, K+ channels in T lymphocytes also containing a summary of the properties of known voltage- and Ca2+-activated K+ channels in lymphocytes and their molecular characteristics, functions, and expression during normal development, mitogen activation, and in autoimmune disorders are discussed. In addition, the chapter describes the coordinated activity of Ca2+ and K+ channels that underlies the mitogen-stimulated Ca2+ signaling." @default.
• W963922907 created "2016-06-24" @default.
• W963922907 creator A5027032779 @default.
• W963922907 creator A5043567383 @default.
• W963922907 creator A5056296835 @default.
• W963922907 date "1991-01-01" @default.
• W963922907 modified "2023-09-25" @default.
• W963922907 title "Chapter 11 Potassium Channels in Development, Activation, and Disease in T Lymphocytes" @default.
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