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• W96403460 endingPage "81" @default.
• W96403460 startingPage "1" @default.
• W96403460 abstract "Three peculiar features have developed in recent years regarding the concept of immunological surveillance (IS). Firstly, the interest in the subject by bona fide immunologists who in the past only had marginal attachment to tumor immunology [1–7], in one case producing actual experimental work [2, 3] and in another [7] by involvement in natural killer (NK) cell research. Secondly, the possible ‘rescue’ of IS [8] as a viable hypothesis by the recent explosion of information on natural-cell-mediated cytotoxicity (N-CMC), especially on NK cells and similar effector mechanisms in animals and humans [9]. The third, and most important point concerning the actual role of the IS hypothesis in the analysis of clinical data, will be discussed at the end of this Introduction. Implied in the first point are also the views that NK cells may be possible mediators of IS [3, 6, 7], with very little else that can be considered as new insights into the problem. Especially since the possible role of NK cells in IS was proposed some time ago by several tumor immunologists [10–14] as well as by researchers in the NK area [12–14]. What was aptly termed as the ‘rescue’ of IS by NK cells [8] can still be considered simply as an adjustment of this persistent theory to the total debacle of the concept of IS as a general phenomenon that applies to all forms of malignancy and to the notion of being mediated by T cells, as originally proposed by Burnet [15]." @default.
• W96403460 created "2016-06-24" @default.
• W96403460 creator A5078785384 @default.
• W96403460 date "1983-01-01" @default.
• W96403460 modified "2023-09-28" @default.
• W96403460 title "The Immunological Surveillance Hypothesis" @default.
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