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- W96403977 abstract "This chapter discusses the historical development of biotechnology with particular emphasis on the recent changes that have seen new products becoming available for both the diagnosis and treatment of disease. The design and implementation of new products dependent, for example, on genetic engineering involves considerations not only of economics but also of safety and regulations. The characterization of restriction endonucleases, enzymes that cut DNA at specific sites, allowed the development, in the mid-1970s, of DNA cloning and recombinant DNA technology. To be expressed, DNA must be introduced into an appropriate cell. This was first achieved with bacteria; however, it is now also possible with animal and plant cells. Hybridoma technology, also developed in the 1970s, makes use of the fact that it is possible to fuse together different types of animal cells. A hybridoma is created by fusing an established cancer cell line, which can be grown in vitro indefinitely, with cells of the immune system, which cannot be grown in vitro ." @default.
- W96403977 created "2016-06-24" @default.
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- W96403977 date "1991-01-01" @default.
- W96403977 modified "2023-09-27" @default.
- W96403977 title "Some perspectives in medical biotechnology" @default.
- W96403977 doi "https://doi.org/10.1016/b978-0-7506-1497-9.50008-8" @default.
- W96403977 hasPublicationYear "1991" @default.
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