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- W964132989 abstract "There is biological evidence for the hypothesis that the frequency of malignant melanoma is influenced by hormonal or reproductive factors. Estrogen receptors have been found in human malignant melanoma cells, though the percent age that are estrogen positive varies considerably by study (Creagan et al. 1980; Fisher et al. 1976). Estrogens and progesterone together or estrogen alone increase the number of melanocytes and the intracellular and extracellular melanin content in guinea pigs (Snell and Bischitz 1960). Ultraviolet light exposure causes darkening of the skin pigment and is believed to play a role in the etiology of melanoma (Holman and Armstrong 1984). Estrogens, whether administered topically (Jadassohn 1958), used to relieve menopausal symptoms (Hamilton 1939), or taken for contraception, can also produce hyperpigmentation, the degree of darkening increasing with duration of use (Carruthers 1966)." @default.
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- W964132989 date "1986-01-01" @default.
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- W964132989 title "Cutaneous Melanoma and Oral Contraceptives: A Review of Case-Control and Cohort Studies" @default.
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- W964132989 doi "https://doi.org/10.1007/978-3-642-82641-2_8" @default.
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