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- W964806850 abstract "Publisher Summary This chapter examines the functional status of the neural systems that subserve memory in the human brain suffering from Alzheimer's disease (AD). Anatomical evidence suggests loss of projection neurons and widespread disconnection of the hippocampal formation and association cortices in AD. This is perhaps most pronounced in the perforant pathway, the projection from the entorhinal cortex to the dentate gyrus that is uniformly destroyed in AD. The new methodologies can examine the functional integrity of hippocampal projections in the postmortem human brain, and through which it is found that there is impairment of the neural elements that are directly affected by the disease process (that is, by neurofibrillary tangles) as well as downstream of the pathological changes. These results highlight the effect of the disease process in disrupting neural systems, thereby causing the impairment of memory function that is so prominent in patients with AD." @default.
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- W964806850 title "Chapter 30 Functional integrity of neural systems related to memory in Alzheimer's disease" @default.
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- W964806850 doi "https://doi.org/10.1016/s0079-6123(08)60791-8" @default.
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