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- W965046598 abstract "piRNA是单链非编码小分子RNA,长度约26-31nt,大部分集中在29-30nt,5’端具有尿嘧啶偏向性(约86%),能够与Argonaute蛋白家族中的Piwi亚家族蛋白相互结合而产生作用。piRNA的功能主要是维持基因组中转座子的正常沉默状态,以防止基因组中转座子爆发而引起相应基因的改变。piRNA与siRNA及miRNA均是近些年发现的非编码小RNA,它们均可通过一套相应的机制进行RNA干扰,在转录、转录后甚至翻译水平对靶基因及蛋白进行调节,它们之间既有联系又有区别。piRNA数据库的建立将对这类小分子RNA的研究有很大的促进作用。" @default.
- W965046598 created "2016-06-24" @default.
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- W965046598 date "2009-01-01" @default.
- W965046598 modified "2023-09-24" @default.
- W965046598 title "一类新的基因沉默小RNA-piRNA(piwi-interacting RNA)" @default.
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