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- W96505718 abstract "Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants that can activate endothelial cells thus leading to atherogenic events. Induction of vascular adhesion molecules is a common feature in inflammatory environments, leading to the early development of atherosclerosis. We have investigated PCB77-induced up-regulation of adhesion molecules through caveolae-regulated signaling in primary mouse aortic endothelial cells (MAECs) and porcine pulmonary artery endothelial cells (PAECs). PCB77 significantly increased the expression of vascular cell adhesion molecule-1 (VCAM-1) and intracellular adhesion molecule-1 (ICAM-1) measured by both Western blot and RT-PCR in a dose dependent manner in both MAECs and PAECs. In addition, the adhesion of monocytes to PCB77-activated endothelial cells was increased in a dose-dependent pattern. Phosphorylation studies of caveolin-1 and related kinases were conducted in endothelial cells containing either functional or siRNA silenced caveolin-1 protein. Activation of these caveolae-associated signaling pathways was decreased in absence of functional caveolae. These data provide the evidence that caveolae may play a critical role in regulating vascular endothelial cell activation and toxicity induced by persistent environmental pollutants such as coplanar PCBs. (Supported by grants from NIH/NIEHS (P42ES07380), the University of Kentucky AES and KRF-2007-357-F00045)" @default.
- W96505718 created "2016-06-24" @default.
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- W96505718 date "2008-03-01" @default.
- W96505718 modified "2023-09-24" @default.
- W96505718 title "PCB77‐induced adhesion molecule expression in primary endothelial cells is mediated through caveolae signaling" @default.
- W96505718 doi "https://doi.org/10.1096/fasebj.22.1_supplement.1071.11" @default.
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