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• W96509724 abstract "Although more doses have been given of the tuberculosis vaccine (BCG) than any other vaccine in history, tuberculosis remains the second leading cause of death due to an infectious agent worldwide. Our understanding of the immune response to the bacterium is incomplete, which has partly been due to a lack of known bacterial T cell epitopes. In recent years, several epitopes have been identified, which has enabled the use of new reagents and assays to study T cell responses. Furthermore, development of recombinant bacteria expressing model antigens has facilitated the use of many more reagents and techniques, as well as allowing us to compare M. tuberculosis-specific T cell responses to those induced by other infectious agents. The aim of this thesis was to better understand the CD8 T cell response to M. tuberculosis and identify factors that regulate the response. We showed that, unexpectedly, the primary CD8 T cell response was more effective than the memory CD8 T cell response to M. tuberculosis, in that primary cells secreted higher levels of IFN-g and were more cytotoxic. We also showed that cytotoxicity and secretion of IFN-g were carried out by distinct M. tuberculosis-specific CD8 T cells, which indicates that there is a functional defect in these cells that is not seen in other infections. Contrary to chronic viral infections, however, M. tuberculosis-specific CD8 T cells did not appear to become exhausted, despite the chronicity of the infection. We further showed that the function of CD8 T cells was influenced by various factors, such as interactions with pre-existing memory cells, the quality of CD4 T cell help and the environment that the cells were primed in. Manipulation of these factors can increase the quality of the immune response, giving multifunctional CD4 and CD8 T cells, as well as CD8 T cells capable of simultaneously being cytotoxic and secreting IFN-g, without altering the bacterium. This indicates that modifications in delivery of tuberculosis vaccines may result in improved efficacy. The work presented may contribute to advances in the development of new tuberculosis vaccines, as well as improvement in efficacy of the existing vaccine." @default.
• W96509724 created "2016-06-24" @default.
• W96509724 creator A5016888268 @default.
• W96509724 date "2010-03-04" @default.
• W96509724 modified "2023-09-24" @default.
• W96509724 title "Function and regulation of CD8 T cells during Mycobacterium tuberculosis infection in a murine model" @default.
• W96509724 cites W1482024060 @default.
• W96509724 cites W1486992536 @default.
• W96509724 cites W1498486243 @default.
• W96509724 cites W1499366632 @default.
• W96509724 cites W1505253301 @default.
• W96509724 cites W1534995493 @default.
• W96509724 cites W1536082352 @default.
• W96509724 cites W1546213590 @default.
• W96509724 cites W1548106543 @default.
• W96509724 cites W1549438168 @default.
• W96509724 cites W1553429135 @default.
• W96509724 cites W1583482357 @default.
• W96509724 cites W1592421151 @default.
• W96509724 cites W1597086056 @default.
• W96509724 cites W1600937541 @default.
• W96509724 cites W1607937732 @default.
• W96509724 cites W1638738262 @default.
• W96509724 cites W167110031 @default.
• W96509724 cites W1678167583 @default.
• W96509724 cites W1683960100 @default.
• W96509724 cites W1744462629 @default.
• W96509724 cites W1765079284 @default.
• W96509724 cites W1793658769 @default.
• W96509724 cites W1842407033 @default.
• W96509724 cites W1848543179 @default.
• W96509724 cites W1852410481 @default.
• W96509724 cites W1853013744 @default.
• W96509724 cites W1874438006 @default.
• W96509724 cites W1902026070 @default.
• W96509724 cites W1914985886 @default.
• W96509724 cites W1930020072 @default.
• W96509724 cites W1930642573 @default.
• W96509724 cites W1965390251 @default.
• W96509724 cites W1966942247 @default.
• W96509724 cites W1967684158 @default.
• W96509724 cites W1970791691 @default.
• W96509724 cites W1973682675 @default.
• W96509724 cites W1974437579 @default.
• W96509724 cites W1978187196 @default.
• W96509724 cites W1978436252 @default.
• W96509724 cites W1980300969 @default.
• W96509724 cites W1981931219 @default.
• W96509724 cites W1983849719 @default.
• W96509724 cites W1984059170 @default.
• W96509724 cites W1984070291 @default.
• W96509724 cites W1985004048 @default.
• W96509724 cites W1989166597 @default.
• W96509724 cites W1989770688 @default.
• W96509724 cites W1991464170 @default.
• W96509724 cites W1991919544 @default.
• W96509724 cites W1992002248 @default.
• W96509724 cites W1992037894 @default.
• W96509724 cites W1992528601 @default.
• W96509724 cites W1993617345 @default.
• W96509724 cites W1998872820 @default.
• W96509724 cites W2001506399 @default.
• W96509724 cites W2004285416 @default.
• W96509724 cites W2004690260 @default.
• W96509724 cites W2005154465 @default.
• W96509724 cites W2008626549 @default.
• W96509724 cites W2011226772 @default.
• W96509724 cites W2013715406 @default.
• W96509724 cites W2014116920 @default.
• W96509724 cites W2014161666 @default.
• W96509724 cites W2014816257 @default.
• W96509724 cites W2015192661 @default.
• W96509724 cites W2015752737 @default.
• W96509724 cites W2015756923 @default.
• W96509724 cites W2016754694 @default.
• W96509724 cites W2017219722 @default.
• W96509724 cites W2019255399 @default.
• W96509724 cites W2020374503 @default.
• W96509724 cites W2023395434 @default.
• W96509724 cites W2025852196 @default.
• W96509724 cites W2026190085 @default.
• W96509724 cites W2026383080 @default.
• W96509724 cites W2030261331 @default.
• W96509724 cites W2034011408 @default.
• W96509724 cites W2034374036 @default.
• W96509724 cites W2034951436 @default.
• W96509724 cites W2036785111 @default.
• W96509724 cites W2038535814 @default.
• W96509724 cites W2040802012 @default.
• W96509724 cites W2041658172 @default.
• W96509724 cites W2041659234 @default.
• W96509724 cites W2046559260 @default.
• W96509724 cites W2048692951 @default.
• W96509724 cites W2049277197 @default.
• W96509724 cites W2051139401 @default.
• W96509724 cites W2052515110 @default.
• W96509724 cites W2054116069 @default.
• W96509724 cites W2056232507 @default.
• W96509724 cites W2059215353 @default.
• W96509724 cites W2060352709 @default.

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