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- W965164132 abstract "Understanding how frequently spontaneous replication arrests occur and how archaea deal with these arrests are very interesting and challenging research topics. Here we will described how genetic and imaging studies have revealed the central role of the archaeal helicase/nuclease Hef belonging to the XPF/MUS81/FANCM family of endonucleases in repair of arrested replication forks. Special focus will be on description of a recently developed combination of genetic and imaging tools to study the dynamic localization of a functional Hef::GFP (Green Fluorescent Protein) fusion protein in the living cells of halophilic archaea Haloferax volcanii. As Archaea provide an excellent and unique model for understanding how DNA replication is regulated to allow replication of a circular DNA molecule either from single or multiple replication origins, we will also summarize recent studies that have revealed peculiar features regarding DNA replication, particularly in halophilic archaea. We strongly believe that fundamental knowledge of our on-going studies will shed light on the evolutionary history of the DNA replication machinery and will help to establish general rules concerning replication restart and the key role of recombination proteins not only in bacteria, yeast and higher eukaryotes but also in archaea." @default.
- W965164132 created "2016-06-24" @default.
- W965164132 creator A5058015886 @default.
- W965164132 creator A5086033761 @default.
- W965164132 creator A5091789775 @default.
- W965164132 date "2015-11-01" @default.
- W965164132 modified "2023-09-25" @default.
- W965164132 title "DNA replication restart and cellular dynamics of Hef helicase/nuclease protein in Haloferax volcanii" @default.
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- W965164132 doi "https://doi.org/10.1016/j.biochi.2015.07.022" @default.
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