Matches in SemOpenAlex for { <https://semopenalex.org/work/W96550900> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W96550900 endingPage "C659" @default.
- W96550900 startingPage "C651" @default.
- W96550900 abstract "Calcium currents (ICa) and barium currents (IBa) were measured in freshly isolated single ferret ventricular myocytes, using the whole cell patch-clamp and perforated patch-clamp techniques with Na and K currents blocked by tetraethylammonium and Cs. The membrane potential (Em) dependence of activation and steady-state inactivation curves were determined using a Boltzmann relation, where E0.5 is the Em at half-maximal conductance. Forskolin (1 microM) increased the rate of ICa inactivation, especially in perforated patch, but slowed IBa inactivation. The acceleration is likely to be due to greater Ca-dependent inactivation of ICa, where the slowing of IBa inactivation may be due to protein kinase A-dependent slowing of Em-dependent inactivation. Forskolin (1-10 microM) also increased ICa amplitude by two- to threefold and shifted the E0.5 for both activation and inactivation to more negative potentials by 7-8 mV. The effect of forskolin on the amplitude of ICa could be reversed by an inhibitor of adenosine 3',5'-cyclic monophosphate-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89; 1-10 microM). However, H-89 did not reverse the shift of E0.5 induced by forskolin. H-89 application by itself does not decrease basal ICa but does shift the E0.5 of both activation and inactivation to more negative values of Em. It is possible that H-89 reverses the shift induced by regulatory phosphorylation (due to forskolin) but induces a coincidental negative shift itself." @default.
- W96550900 created "2016-06-24" @default.
- W96550900 creator A5020824899 @default.
- W96550900 creator A5061257916 @default.
- W96550900 date "1995-03-01" @default.
- W96550900 modified "2023-10-18" @default.
- W96550900 title "Protein kinase inhibitor H-89 reverses forskolin stimulation of cardiac L-type calcium current" @default.
- W96550900 cites W1445544398 @default.
- W96550900 cites W1481438484 @default.
- W96550900 cites W1599059671 @default.
- W96550900 cites W1983918349 @default.
- W96550900 cites W1988838985 @default.
- W96550900 cites W1997727911 @default.
- W96550900 cites W1998341622 @default.
- W96550900 cites W2008858665 @default.
- W96550900 cites W2013576776 @default.
- W96550900 cites W2024770714 @default.
- W96550900 cites W2031806531 @default.
- W96550900 cites W2042646075 @default.
- W96550900 cites W2047316488 @default.
- W96550900 cites W2052501501 @default.
- W96550900 cites W2070965152 @default.
- W96550900 cites W2073860499 @default.
- W96550900 cites W2087012667 @default.
- W96550900 cites W2126578889 @default.
- W96550900 cites W2141349335 @default.
- W96550900 cites W2158479937 @default.
- W96550900 doi "https://doi.org/10.1152/ajpcell.1995.268.3.c651" @default.
- W96550900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7900772" @default.
- W96550900 hasPublicationYear "1995" @default.
- W96550900 type Work @default.
- W96550900 sameAs 96550900 @default.
- W96550900 citedByCount "35" @default.
- W96550900 countsByYear W965509002012 @default.
- W96550900 countsByYear W965509002013 @default.
- W96550900 countsByYear W965509002014 @default.
- W96550900 countsByYear W965509002015 @default.
- W96550900 countsByYear W965509002016 @default.
- W96550900 countsByYear W965509002017 @default.
- W96550900 countsByYear W965509002019 @default.
- W96550900 countsByYear W965509002021 @default.
- W96550900 crossrefType "journal-article" @default.
- W96550900 hasAuthorship W96550900A5020824899 @default.
- W96550900 hasAuthorship W96550900A5061257916 @default.
- W96550900 hasConcept C12554922 @default.
- W96550900 hasConcept C126322002 @default.
- W96550900 hasConcept C134018914 @default.
- W96550900 hasConcept C147944092 @default.
- W96550900 hasConcept C184235292 @default.
- W96550900 hasConcept C185263204 @default.
- W96550900 hasConcept C185592680 @default.
- W96550900 hasConcept C24998067 @default.
- W96550900 hasConcept C2779033064 @default.
- W96550900 hasConcept C2779276759 @default.
- W96550900 hasConcept C519063684 @default.
- W96550900 hasConcept C55493867 @default.
- W96550900 hasConcept C71924100 @default.
- W96550900 hasConcept C86803240 @default.
- W96550900 hasConcept C97029542 @default.
- W96550900 hasConceptScore W96550900C12554922 @default.
- W96550900 hasConceptScore W96550900C126322002 @default.
- W96550900 hasConceptScore W96550900C134018914 @default.
- W96550900 hasConceptScore W96550900C147944092 @default.
- W96550900 hasConceptScore W96550900C184235292 @default.
- W96550900 hasConceptScore W96550900C185263204 @default.
- W96550900 hasConceptScore W96550900C185592680 @default.
- W96550900 hasConceptScore W96550900C24998067 @default.
- W96550900 hasConceptScore W96550900C2779033064 @default.
- W96550900 hasConceptScore W96550900C2779276759 @default.
- W96550900 hasConceptScore W96550900C519063684 @default.
- W96550900 hasConceptScore W96550900C55493867 @default.
- W96550900 hasConceptScore W96550900C71924100 @default.
- W96550900 hasConceptScore W96550900C86803240 @default.
- W96550900 hasConceptScore W96550900C97029542 @default.
- W96550900 hasIssue "3" @default.
- W96550900 hasLocation W965509001 @default.
- W96550900 hasLocation W965509002 @default.
- W96550900 hasOpenAccess W96550900 @default.
- W96550900 hasPrimaryLocation W965509001 @default.
- W96550900 hasRelatedWork W1975696001 @default.
- W96550900 hasRelatedWork W2007885146 @default.
- W96550900 hasRelatedWork W2008261372 @default.
- W96550900 hasRelatedWork W2053936620 @default.
- W96550900 hasRelatedWork W2054992011 @default.
- W96550900 hasRelatedWork W2058991568 @default.
- W96550900 hasRelatedWork W2064416809 @default.
- W96550900 hasRelatedWork W2089805841 @default.
- W96550900 hasRelatedWork W2104693712 @default.
- W96550900 hasRelatedWork W2129632392 @default.
- W96550900 hasVolume "268" @default.
- W96550900 isParatext "false" @default.
- W96550900 isRetracted "false" @default.
- W96550900 magId "96550900" @default.
- W96550900 workType "article" @default.