Matches in SemOpenAlex for { <https://semopenalex.org/work/W9655217> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W9655217 endingPage "215" @default.
- W9655217 startingPage "209" @default.
- W9655217 abstract "Large populations of deletions of human mitochondrial DNA (δ-mtDNAs), often associated with sporadic Kearns-Sayre syndrome (KSS), are thought to arise as a clonal expansion of an initial mutation event occurring early in oogenesis or embryogenesis. This hypothesis implies that a single mutated molecule is amplified during the lifespan of the patient, perhaps because δ-mtDNAs, which are smaller than wild-type genomes (wt-mtDNAs), have a replicative advantage over wt-mtDNAs. To address this question, we compared the rates of completion of mtDNA circles in fibroblasts containing a heteroplasmic population of 16.6-kb wt-mtDNAs and partially-deleted 9.1-kb δ-mtDNAs (i.e. a 7.5-kb deletion). We found essentially no difference in the rate of completion of δ-mtDNAs as compared to wt-mtDNAs (i.e. equal numbers of wt-mtDNA and δ-mtDNA circles were completed per unit time). Thus, the massive proliferation of δ-mtDNAs in KSS muscle is likely not due simply to differential rates of duplication of smaller genomes." @default.
- W9655217 created "2016-06-24" @default.
- W9655217 creator A5060561492 @default.
- W9655217 creator A5071211755 @default.
- W9655217 date "1995-01-01" @default.
- W9655217 modified "2023-09-23" @default.
- W9655217 title "Replication of a heteroplasmic population of normal and partially-deleted human mitochondrial genomes" @default.
- W9655217 cites W1966148532 @default.
- W9655217 cites W1996052541 @default.
- W9655217 cites W2002736146 @default.
- W9655217 cites W2022312470 @default.
- W9655217 cites W2033743648 @default.
- W9655217 cites W2043015105 @default.
- W9655217 cites W2044711106 @default.
- W9655217 cites W2075542990 @default.
- W9655217 cites W2077414996 @default.
- W9655217 cites W2088749854 @default.
- W9655217 cites W2090805983 @default.
- W9655217 cites W2109291482 @default.
- W9655217 cites W2152832510 @default.
- W9655217 cites W2328596111 @default.
- W9655217 cites W4243977051 @default.
- W9655217 doi "https://doi.org/10.1016/b978-0-444-82235-2.50039-4" @default.
- W9655217 hasPublicationYear "1995" @default.
- W9655217 type Work @default.
- W9655217 sameAs 9655217 @default.
- W9655217 citedByCount "8" @default.
- W9655217 crossrefType "book-chapter" @default.
- W9655217 hasAuthorship W9655217A5060561492 @default.
- W9655217 hasAuthorship W9655217A5071211755 @default.
- W9655217 hasConcept C104317684 @default.
- W9655217 hasConcept C141231307 @default.
- W9655217 hasConcept C153911025 @default.
- W9655217 hasConcept C181561989 @default.
- W9655217 hasConcept C24586158 @default.
- W9655217 hasConcept C2908647359 @default.
- W9655217 hasConcept C54355233 @default.
- W9655217 hasConcept C71924100 @default.
- W9655217 hasConcept C86803240 @default.
- W9655217 hasConcept C99454951 @default.
- W9655217 hasConceptScore W9655217C104317684 @default.
- W9655217 hasConceptScore W9655217C141231307 @default.
- W9655217 hasConceptScore W9655217C153911025 @default.
- W9655217 hasConceptScore W9655217C181561989 @default.
- W9655217 hasConceptScore W9655217C24586158 @default.
- W9655217 hasConceptScore W9655217C2908647359 @default.
- W9655217 hasConceptScore W9655217C54355233 @default.
- W9655217 hasConceptScore W9655217C71924100 @default.
- W9655217 hasConceptScore W9655217C86803240 @default.
- W9655217 hasConceptScore W9655217C99454951 @default.
- W9655217 hasLocation W96552171 @default.
- W9655217 hasOpenAccess W9655217 @default.
- W9655217 hasPrimaryLocation W96552171 @default.
- W9655217 hasRelatedWork W2028174481 @default.
- W9655217 hasRelatedWork W2054478802 @default.
- W9655217 hasRelatedWork W2071668318 @default.
- W9655217 hasRelatedWork W2111976489 @default.
- W9655217 hasRelatedWork W2115003961 @default.
- W9655217 hasRelatedWork W2141451746 @default.
- W9655217 hasRelatedWork W2149600853 @default.
- W9655217 hasRelatedWork W2407126217 @default.
- W9655217 hasRelatedWork W2980068720 @default.
- W9655217 hasRelatedWork W3001134453 @default.
- W9655217 isParatext "false" @default.
- W9655217 isRetracted "false" @default.
- W9655217 magId "9655217" @default.
- W9655217 workType "book-chapter" @default.