FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W9660048> ?p ?o ?g. }

• W9660048 endingPage "8" @default.
• W9660048 startingPage "1253" @default.
• W9660048 abstract "The regenerating gene (Reg), encoding lectin-related protein, was originally isolated from a rat regenerating pancreatic islets. Interleukin-22 (IL-22), a recently identified cytokine, is produced by Th 17 cells and natural killer cells. Both of them have been shown to play an important role in controlling tissue repair. But, it is unclear whether the IL-22/Reg axis is involved in liver regeneration and the improvement of liver function in a rat model of acute liver injury.We investigated the expression levels of Reg proteins after IL-22 stimulation in a rat model of acute liver injury, and estimated the effects of Reg proteins ameliorating acute liver injury.Western blot was used to measure the expressions of Reg I, Reg III, Reg IV proteins after treatment with recombinant lentivirus IL-22. At the same time, the expression levels of TB, ALT, AST, endotoxin (ETM), superoxide dismutase (SOD), malondialdehyde (MDA) were detected by related reagents.In a rat model of acute liver injury, the expression levels of Reg I, Reg III, Reg IV proteins were increased after treatment with IL-22 recombinant lentivirus compared with treatment with lentivirus-empty vector, especially, Reg IV protein expression. Meanwhile, treatment with IL-22 recombinant lentivirus reduced serum levels of TB, ALT, AST, ETM, and decreased MAD levels in rat liver tissues, but increased SOD levels in rat liver tissues.IL-22 stimulation enhanced the expressions of Reg proteins in liver cell, especially, Reg IV protein, and ameliorated liver injury in a rat model of acute liver injury. Reg protein, especially Reg IV protein, might act as a biological mediator of immune cell-derived IL-22 in the recovering mechanism of liver injury." @default.
• W9660048 created "2016-06-24" @default.
• W9660048 creator A5041284064 @default.
• W9660048 creator A5047532135 @default.
• W9660048 creator A5080985564 @default.
• W9660048 creator A5081554265 @default.
• W9660048 date "2015-01-01" @default.
• W9660048 modified "2023-09-27" @default.
• W9660048 title "Up-regulated Reg proteins induced by Interleukin-22 treatment ameliorate acute liver injury in rat model." @default.
• W9660048 cites W1531601693 @default.
• W9660048 cites W1576903429 @default.
• W9660048 cites W1752683265 @default.
• W9660048 cites W1983205679 @default.
• W9660048 cites W1987389251 @default.
• W9660048 cites W1994509817 @default.
• W9660048 cites W2005359518 @default.
• W9660048 cites W2013349369 @default.
• W9660048 cites W2016031589 @default.
• W9660048 cites W2025421728 @default.
• W9660048 cites W2031038184 @default.
• W9660048 cites W2033283529 @default.
• W9660048 cites W2036312906 @default.
• W9660048 cites W2040015333 @default.
• W9660048 cites W2043493252 @default.
• W9660048 cites W2053820570 @default.
• W9660048 cites W2055060301 @default.
• W9660048 cites W2056005334 @default.
• W9660048 cites W2062564526 @default.
• W9660048 cites W2075848641 @default.
• W9660048 cites W2077627123 @default.
• W9660048 cites W2085457180 @default.
• W9660048 cites W2092701974 @default.
• W9660048 cites W2093005090 @default.
• W9660048 cites W2093739693 @default.
• W9660048 cites W2102754351 @default.
• W9660048 cites W2104201959 @default.
• W9660048 cites W2107066107 @default.
• W9660048 cites W2120420911 @default.
• W9660048 cites W2125410679 @default.
• W9660048 cites W2135261346 @default.
• W9660048 cites W2139121810 @default.
• W9660048 cites W2143076511 @default.
• W9660048 cites W2143364414 @default.
• W9660048 cites W2147833105 @default.
• W9660048 cites W4211223836 @default.
• W9660048 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4358576" @default.
• W9660048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25785121" @default.
• W9660048 hasPublicationYear "2015" @default.
• W9660048 type Work @default.
• W9660048 sameAs 9660048 @default.
• W9660048 citedByCount "3" @default.
• W9660048 countsByYear W96600482016 @default.
• W9660048 countsByYear W96600482020 @default.
• W9660048 countsByYear W96600482022 @default.
• W9660048 crossrefType "journal-article" @default.
• W9660048 hasAuthorship W9660048A5041284064 @default.
• W9660048 hasAuthorship W9660048A5047532135 @default.
• W9660048 hasAuthorship W9660048A5080985564 @default.
• W9660048 hasAuthorship W9660048A5081554265 @default.
• W9660048 hasConcept C104317684 @default.
• W9660048 hasConcept C126322002 @default.
• W9660048 hasConcept C153911025 @default.
• W9660048 hasConcept C16685009 @default.
• W9660048 hasConcept C203014093 @default.
• W9660048 hasConcept C2775838275 @default.
• W9660048 hasConcept C2776151105 @default.
• W9660048 hasConcept C2776415932 @default.
• W9660048 hasConcept C2776637226 @default.
• W9660048 hasConcept C40767141 @default.
• W9660048 hasConcept C55493867 @default.
• W9660048 hasConcept C71924100 @default.
• W9660048 hasConcept C86803240 @default.
• W9660048 hasConceptScore W9660048C104317684 @default.
• W9660048 hasConceptScore W9660048C126322002 @default.
• W9660048 hasConceptScore W9660048C153911025 @default.
• W9660048 hasConceptScore W9660048C16685009 @default.
• W9660048 hasConceptScore W9660048C203014093 @default.
• W9660048 hasConceptScore W9660048C2775838275 @default.
• W9660048 hasConceptScore W9660048C2776151105 @default.
• W9660048 hasConceptScore W9660048C2776415932 @default.
• W9660048 hasConceptScore W9660048C2776637226 @default.
• W9660048 hasConceptScore W9660048C40767141 @default.
• W9660048 hasConceptScore W9660048C55493867 @default.
• W9660048 hasConceptScore W9660048C71924100 @default.
• W9660048 hasConceptScore W9660048C86803240 @default.
• W9660048 hasIssue "1" @default.
• W9660048 hasLocation W96600481 @default.
• W9660048 hasOpenAccess W9660048 @default.
• W9660048 hasPrimaryLocation W96600481 @default.
• W9660048 hasRelatedWork W2339270935 @default.
• W9660048 hasRelatedWork W2350055354 @default.
• W9660048 hasRelatedWork W2350566209 @default.
• W9660048 hasRelatedWork W2354179186 @default.
• W9660048 hasRelatedWork W2359256335 @default.
• W9660048 hasRelatedWork W2368739352 @default.
• W9660048 hasRelatedWork W2378774708 @default.
• W9660048 hasRelatedWork W2380817849 @default.
• W9660048 hasRelatedWork W2392626361 @default.

• next