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• W96614748 abstract "Research Article15 April 1996free access Muscle wasting and dedifferentiation induced by oxidative stress in a murine model of cachexia is prevented by inhibitors of nitric oxide synthesis and antioxidants. M. Buck M. Buck Department of Medicine, Veterans Affairs Medical Center, San Diego, CA, USA. Search for more papers by this author M. Chojkier M. Chojkier Department of Medicine, Veterans Affairs Medical Center, San Diego, CA, USA. Search for more papers by this author M. Buck M. Buck Department of Medicine, Veterans Affairs Medical Center, San Diego, CA, USA. Search for more papers by this author M. Chojkier M. Chojkier Department of Medicine, Veterans Affairs Medical Center, San Diego, CA, USA. Search for more papers by this author Author Information M. Buck1 and M. Chojkier1 1Department of Medicine, Veterans Affairs Medical Center, San Diego, CA, USA. The EMBO Journal (1996)15:1753-1765https://doi.org/10.1002/j.1460-2075.1996.tb00524.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Muscle wasting is a critical feature of patients afflicted by AIDS or cancer. In a murine model of muscle wasting, tumor necrosis factor alpha (TNF alpha) induces oxidative stress and nitric oxide synthase (NOS) in skeletal muscle, leading to decreased myosin creatinine phosphokinase (MCK) expression and binding activities. The impaired MCK-E box binding activities resulted from abnormal myogenin-Jun-D complexes, and were normalized by the addition of Jun-D, dithiothreitol or Ref-1, a nuclear redox protein. Treatment of skeletal muscle cells with a phorbol ester, a superoxide-generating system, an NO donor or a Jun-D antisense oligonucleotide decreased Jun-D activity and transcription from the MCK-E box, which were prevented by antioxidants, a scavenger of reducing equivalents, a NOS inhibitor and/or overexpression of Jun-D. The decreased body weight, muscle wasting and skeletal muscle molecular abnormalities of cachexia were prevented by treatment of TNF alpha mice with the antioxidants D-alpha-tocopherol of BW755c, or the NOS inhibitor nitro-L-arginine. Previous ArticleNext Article Volume 15Issue 81 April 1996In this issue RelatedDetailsLoading ..." @default.
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• W96614748 creator A5054228197 @default.
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• W96614748 date "1996-04-01" @default.
• W96614748 modified "2023-10-15" @default.
• W96614748 title "Muscle wasting and dedifferentiation induced by oxidative stress in a murine model of cachexia is prevented by inhibitors of nitric oxide synthesis and antioxidants." @default.
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• W96614748 doi "https://doi.org/10.1002/j.1460-2075.1996.tb00524.x" @default.
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