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- W966259568 abstract "Exercise training increases Ca2+-dependent basal active tone in coronary arterioles distal to chronic occlusion (collateral-dependent). In the present study, we tested the hypothesis that agonist-mediated contractile responses in collateral-dependent coronary arterioles of exercise trained pigs would be enhanced and attributable to Ca2+ sensitization. Ameroid occluders were surgically placed around the proximal left circumflex coronary artery of miniswine. Arterioles (~150 μm ID) were isolated from both the collateral-dependent and nonoccluded regions of sedentary (SED; pen-confined) and exercise trained (EX; treadmill; 14 wks) pigs and studied using microvessel myographs and standard isometric techniques. Contraction to endothelin-1 in collateral-dependent arterioles was not altered in SED animals, but in EX pigs displayed enhanced constriction vs. nonoccluded arterioles. Importantly, simultaneous measures of endothelin-mediated tension and myoplasmic free Ca2+ (fura-2) revealed enhanced Ca2+ sensitivity in collateral-dependent arterioles of EX animals. Further, inhibition of Rho-kinase (Y-27632; 1 μM) reversed the enhanced contraction in collateral-dependent arterioles of EX pigs. Taken together, our data indicate that coronary arterioles isolated from the collateral-dependent region of EX animals display increased endothelin-stimulated contraction that is attributable to Rho-kinase-mediated Ca2+ sensitization. Support: NIH HL64931, HL62552" @default.
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- W966259568 date "2006-03-01" @default.
- W966259568 modified "2023-10-14" @default.
- W966259568 title "Increased Ca 2+ sensitization in collateral‐dependent coronary arterioles of exercise trained swine: role of Rho‐kinase" @default.
- W966259568 doi "https://doi.org/10.1096/fasebj.20.4.a730-a" @default.
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