FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W966348844> ?p ?o ?g. }

• W966348844 endingPage "884" @default.
• W966348844 startingPage "875" @default.
• W966348844 abstract "Adriamycin (ADM) is an antineoplastic agent that is effective against a wide range of cancers, but cardiac toxicity limits its clinical application. Ginsenoside Rg3 (Rg3), an anti-cancer active ingredient of Panax ginseng, was reported to have anti-oxidative, anti-apoptotic, and cardioprotective properties.The current study aimed to investigate the possible protective effect of Rg3 against ADM-induced cardiotoxicity.The activity of Rg3 to improve endothelial dysfunction was processed both in vivo and in vitro.We investigated the cardioprotective effect of Rg3 on ADM treated rats by echocardiography. The endothelial dysfunction was assessed using an aortic ring assay. Cardiac microvascular endothelial cells were cultured to investigate the effects of Rg3 on ADM-treated cells.Results showed that Rg3 could ameliorate the decrease in the ejection fraction and fractional shortening that was induced by ADM, and improve the left ventricular outflow. The aortic ring assay showed that Rg3 could partially recover the abnormal vascular function. In vitro studies showed that Rg3 could promote cell viability to attenuate ADM induced oxidative damage and apoptosis. This counteraction was achieved partially via activation of the Nrf2-ARE pathway through the activation of Akt.These findings elucidated the potential of Rg3 as a promising reagent for treating ADM-induced cardiotoxicity in clinic." @default.
• W966348844 created "2016-06-24" @default.
• W966348844 creator A5020302124 @default.
• W966348844 creator A5029363724 @default.
• W966348844 creator A5031639923 @default.
• W966348844 creator A5050852420 @default.
• W966348844 creator A5063320195 @default.
• W966348844 creator A5068080767 @default.
• W966348844 creator A5078126271 @default.
• W966348844 creator A5086290413 @default.
• W966348844 date "2015-09-01" @default.
• W966348844 modified "2023-10-11" @default.
• W966348844 title "Ginsenoside Rg3 antagonizes adriamycin-induced cardiotoxicity by improving endothelial dysfunction from oxidative stress via upregulating the Nrf2-ARE pathway through the activation of akt" @default.
• W966348844 cites W1785455093 @default.
• W966348844 cites W1828224642 @default.
• W966348844 cites W1964179489 @default.
• W966348844 cites W1968045613 @default.
• W966348844 cites W1969134590 @default.
• W966348844 cites W1969236715 @default.
• W966348844 cites W1972331889 @default.
• W966348844 cites W1973118925 @default.
• W966348844 cites W1986654678 @default.
• W966348844 cites W1987593270 @default.
• W966348844 cites W1995089262 @default.
• W966348844 cites W2029947074 @default.
• W966348844 cites W2030926513 @default.
• W966348844 cites W2036956805 @default.
• W966348844 cites W2039456527 @default.
• W966348844 cites W2039898654 @default.
• W966348844 cites W2046401757 @default.
• W966348844 cites W2051092344 @default.
• W966348844 cites W2054018704 @default.
• W966348844 cites W2058263096 @default.
• W966348844 cites W2060697601 @default.
• W966348844 cites W2076935230 @default.
• W966348844 cites W2078532650 @default.
• W966348844 cites W2087311397 @default.
• W966348844 cites W2108649922 @default.
• W966348844 cites W2118621558 @default.
• W966348844 cites W2122772258 @default.
• W966348844 cites W2137703201 @default.
• W966348844 cites W2151163583 @default.
• W966348844 cites W2156292009 @default.
• W966348844 doi "https://doi.org/10.1016/j.phymed.2015.06.010" @default.
• W966348844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26321736" @default.
• W966348844 hasPublicationYear "2015" @default.
• W966348844 type Work @default.
• W966348844 sameAs 966348844 @default.
• W966348844 citedByCount "70" @default.
• W966348844 countsByYear W9663488442015 @default.
• W966348844 countsByYear W9663488442016 @default.
• W966348844 countsByYear W9663488442017 @default.
• W966348844 countsByYear W9663488442018 @default.
• W966348844 countsByYear W9663488442019 @default.
• W966348844 countsByYear W9663488442020 @default.
• W966348844 countsByYear W9663488442021 @default.
• W966348844 countsByYear W9663488442022 @default.
• W966348844 countsByYear W9663488442023 @default.
• W966348844 crossrefType "journal-article" @default.
• W966348844 hasAuthorship W966348844A5020302124 @default.
• W966348844 hasAuthorship W966348844A5029363724 @default.
• W966348844 hasAuthorship W966348844A5031639923 @default.
• W966348844 hasAuthorship W966348844A5050852420 @default.
• W966348844 hasAuthorship W966348844A5063320195 @default.
• W966348844 hasAuthorship W966348844A5068080767 @default.
• W966348844 hasAuthorship W966348844A5078126271 @default.
• W966348844 hasAuthorship W966348844A5086290413 @default.
• W966348844 hasConcept C126322002 @default.
• W966348844 hasConcept C142724271 @default.
• W966348844 hasConcept C185592680 @default.
• W966348844 hasConcept C190283241 @default.
• W966348844 hasConcept C204787440 @default.
• W966348844 hasConcept C2776151105 @default.
• W966348844 hasConcept C2776539398 @default.
• W966348844 hasConcept C2778233292 @default.
• W966348844 hasConcept C2779232237 @default.
• W966348844 hasConcept C2780972559 @default.
• W966348844 hasConcept C29730261 @default.
• W966348844 hasConcept C53227056 @default.
• W966348844 hasConcept C55493867 @default.
• W966348844 hasConcept C71924100 @default.
• W966348844 hasConcept C75217442 @default.
• W966348844 hasConcept C98274493 @default.
• W966348844 hasConceptScore W966348844C126322002 @default.
• W966348844 hasConceptScore W966348844C142724271 @default.
• W966348844 hasConceptScore W966348844C185592680 @default.
• W966348844 hasConceptScore W966348844C190283241 @default.
• W966348844 hasConceptScore W966348844C204787440 @default.
• W966348844 hasConceptScore W966348844C2776151105 @default.
• W966348844 hasConceptScore W966348844C2776539398 @default.
• W966348844 hasConceptScore W966348844C2778233292 @default.
• W966348844 hasConceptScore W966348844C2779232237 @default.
• W966348844 hasConceptScore W966348844C2780972559 @default.
• W966348844 hasConceptScore W966348844C29730261 @default.
• W966348844 hasConceptScore W966348844C53227056 @default.
• W966348844 hasConceptScore W966348844C55493867 @default.
• W966348844 hasConceptScore W966348844C71924100 @default.
• W966348844 hasConceptScore W966348844C75217442 @default.

• next