FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W966365785> ?p ?o ?g. }

• W966365785 endingPage "51" @default.
• W966365785 startingPage "45" @default.
• W966365785 abstract "Lhx9 is a member of the LIM-homeodomain gene family necessary for the correct development of many organs including gonads, limbs, heart and the nervous system. In the context of limb development, Lhx9 has been implicated as an integrator for Fibroblast growth factor (FGF) and Sonic hedgehog (Shh) signalling required for proximal-distal (PD) and anterior-posterior (AP) development of the limb. Three splice variants of the Lhx9 transcript are expressed during development, two of which are predicted to act in a dominant negative fashion, competing with the DNA binding version of Lhx9 for binding to cofactors via the LIM-domain. We examined the expression pattern for the three alternative splice forms of Lhx9; Lhx9α, Lhx9β and Lhx9c during early limb development. We have found that of the three Lhx9 isoforms, only Lhx9α and Lhx9c (intact homeodomain) are expressed during early limb development, each with their own distinct expression pattern. Additionally we determined that Lhx9 expression overlaps with FGF10 expression in the developing limb bud mesenchyme. Limb bud explant cultures, in the presence of signalling pathway inhibitors, also indicated that Lhx9 mRNA expression in the limb bud was dependent on FGF signalling." @default.
• W966365785 created "2016-06-24" @default.
• W966365785 creator A5045957624 @default.
• W966365785 creator A5062067044 @default.
• W966365785 date "2015-09-01" @default.
• W966365785 modified "2023-09-25" @default.
• W966365785 title "Lhx9 gene expression during early limb development in mice requires the FGF signalling pathway" @default.
• W966365785 cites W1273298230 @default.
• W966365785 cites W1660610441 @default.
• W966365785 cites W1974208182 @default.
• W966365785 cites W1975815877 @default.
• W966365785 cites W1985823406 @default.
• W966365785 cites W2000054590 @default.
• W966365785 cites W2009092227 @default.
• W966365785 cites W2011284893 @default.
• W966365785 cites W2027575989 @default.
• W966365785 cites W2029676157 @default.
• W966365785 cites W2030789263 @default.
• W966365785 cites W2032663621 @default.
• W966365785 cites W2055102377 @default.
• W966365785 cites W2065549683 @default.
• W966365785 cites W2077802746 @default.
• W966365785 cites W2091815212 @default.
• W966365785 cites W2100143758 @default.
• W966365785 cites W2110873651 @default.
• W966365785 cites W2111256185 @default.
• W966365785 cites W2113028019 @default.
• W966365785 cites W2132520926 @default.
• W966365785 cites W2145308907 @default.
• W966365785 doi "https://doi.org/10.1016/j.gep.2015.07.002" @default.
• W966365785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26220830" @default.
• W966365785 hasPublicationYear "2015" @default.
• W966365785 type Work @default.
• W966365785 sameAs 966365785 @default.
• W966365785 citedByCount "20" @default.
• W966365785 countsByYear W9663657852017 @default.
• W966365785 countsByYear W9663657852018 @default.
• W966365785 countsByYear W9663657852019 @default.
• W966365785 countsByYear W9663657852020 @default.
• W966365785 countsByYear W9663657852022 @default.
• W966365785 countsByYear W9663657852023 @default.
• W966365785 crossrefType "journal-article" @default.
• W966365785 hasAuthorship W966365785A5045957624 @default.
• W966365785 hasAuthorship W966365785A5062067044 @default.
• W966365785 hasConcept C102309675 @default.
• W966365785 hasConcept C104317684 @default.
• W966365785 hasConcept C121587040 @default.
• W966365785 hasConcept C134018914 @default.
• W966365785 hasConcept C145103041 @default.
• W966365785 hasConcept C146759223 @default.
• W966365785 hasConcept C170493617 @default.
• W966365785 hasConcept C196843134 @default.
• W966365785 hasConcept C25770073 @default.
• W966365785 hasConcept C2776340970 @default.
• W966365785 hasConcept C2776637008 @default.
• W966365785 hasConcept C2780915607 @default.
• W966365785 hasConcept C54355233 @default.
• W966365785 hasConcept C62478195 @default.
• W966365785 hasConcept C74373430 @default.
• W966365785 hasConcept C84013057 @default.
• W966365785 hasConcept C86339819 @default.
• W966365785 hasConcept C86370654 @default.
• W966365785 hasConcept C86803240 @default.
• W966365785 hasConcept C95444343 @default.
• W966365785 hasConceptScore W966365785C102309675 @default.
• W966365785 hasConceptScore W966365785C104317684 @default.
• W966365785 hasConceptScore W966365785C121587040 @default.
• W966365785 hasConceptScore W966365785C134018914 @default.
• W966365785 hasConceptScore W966365785C145103041 @default.
• W966365785 hasConceptScore W966365785C146759223 @default.
• W966365785 hasConceptScore W966365785C170493617 @default.
• W966365785 hasConceptScore W966365785C196843134 @default.
• W966365785 hasConceptScore W966365785C25770073 @default.
• W966365785 hasConceptScore W966365785C2776340970 @default.
• W966365785 hasConceptScore W966365785C2776637008 @default.
• W966365785 hasConceptScore W966365785C2780915607 @default.
• W966365785 hasConceptScore W966365785C54355233 @default.
• W966365785 hasConceptScore W966365785C62478195 @default.
• W966365785 hasConceptScore W966365785C74373430 @default.
• W966365785 hasConceptScore W966365785C84013057 @default.
• W966365785 hasConceptScore W966365785C86339819 @default.
• W966365785 hasConceptScore W966365785C86370654 @default.
• W966365785 hasConceptScore W966365785C86803240 @default.
• W966365785 hasConceptScore W966365785C95444343 @default.
• W966365785 hasIssue "1-2" @default.
• W966365785 hasLocation W9663657851 @default.
• W966365785 hasLocation W9663657852 @default.
• W966365785 hasOpenAccess W966365785 @default.
• W966365785 hasPrimaryLocation W9663657851 @default.
• W966365785 hasRelatedWork W1754199354 @default.
• W966365785 hasRelatedWork W1993101422 @default.
• W966365785 hasRelatedWork W2069682659 @default.
• W966365785 hasRelatedWork W2092672917 @default.
• W966365785 hasRelatedWork W2114906532 @default.
• W966365785 hasRelatedWork W2181453860 @default.
• W966365785 hasRelatedWork W28865945 @default.
• W966365785 hasRelatedWork W3012057842 @default.
• W966365785 hasRelatedWork W4210256233 @default.

• next