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- W96657836 abstract "This chapter reviews the biological features of osteoclast development. Osteoclasts are hematopoietic cells that have bone-resorbing activity, and participate in bone remodeling and bone marrow formation. Mature functional osteoclasts are large multinuclear cells consisting of multiple osteoclasts fused with each other. Since embryonic stem (ES) cells have the potential to differentiate into all cell lineages, it should be possible to derive any cell lineage by appropriate induction of ES cells in culture. Osteoclasts, derived from hematopoietic stem cells, participate in bone remodeling and form bone marrow cavities through their bone resorbing activity. The precursors share their characteristics with the precursors of monocytic lineage cells, such as macrophages and dendritic cells. In one-step culture, a wider range of cell lineages could be observed in a dish compared with cloned stromal cell (OP9) cultures. In addition to hematopoietic lineages, at least endothelial cells, osteoblasts, myocardial cells, melanocytes, and pigmented epithelial cells are observed. Osteoblasts build the bone, endothelial cells invade the bone, and osteoclasts resorb the bone and make bone marrow cavity. These two lineages of cells are closely associated and located as concentric circles." @default.
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- W96657836 date "2004-01-01" @default.
- W96657836 modified "2023-10-16" @default.
- W96657836 title "Osteoclast Lineage" @default.
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- W96657836 doi "https://doi.org/10.1016/b978-012436643-5/50036-5" @default.
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