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- W967493419 abstract "More than a century ago, Malmsten (1859) demonstrated the strong relationship between thrombosis and atherosclerosis on coronary arteries. Rokitansky (1852) observed that the incorporation of a mural coagulum was a primary event in the atherogenesis of man and hypothesized that material derived from the bloodstream and “fibrin deposition” in the arterial wall caused “incrustation” and subsequent cellular “fibrotic transformation”. As early as 1882, Bizzozero stressed the role of platelets in this particular process and in atherogenesis and reported for the first time, in a microscopic study, platelet adhesion and aggregation following an experimental mechanical injury to mesenteric arteries in animals. Similar findings on the involvement of platelets (parietal microthrombosis) in atherosclerosis were later obtained with the use of different techniques by Duguid (1946). Since then, various studies have emphasized the incorporation of a thrombus, which is either generated by plasmatic coagulation or by platelets alone, yet mostly by combined action as a very early event in the development of human atherosclerotic lesions." @default.
- W967493419 created "2016-06-24" @default.
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- W967493419 date "1997-01-01" @default.
- W967493419 modified "2023-09-27" @default.
- W967493419 title "Platelets and the Vascular System: Atherosclerosis, Thrombosis, Myocardial Infarction" @default.
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- W967493419 doi "https://doi.org/10.1007/978-3-642-60639-7_25" @default.
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