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- W967575156 abstract "Transcranial direct current stimulation (tDCS) is a potential alternative treatment option for major depressive episodes (MDE).We address the efficacy and safety of tDCS in MDE.The outcome measures were Hedges' g for continuous depression ratings, and categorical response and remission rates.A random effects model indicated that tDCS was superior to sham tDCS (k=11, N=393, g=0.30, 95% CI=[0.04, 0.57], p=0.027). Adjunctive antidepressant medication and cognitive control training negatively impacted on the treatment effect. The pooled log odds ratios (LOR) for response and remission were positive, but statistically non-significant (response: k=9, LOR=0.36, 95% CI[-0.16, 0.88], p=0.176, remission: k=9, LOR=0.25, 95% CI [-0.42, 0.91], p=0.468). We estimated that for a study to detect the pooled continuous effect (g=0.30) at 80% power (alpha=0.05), a total N of at least 346 would be required (with the total N required to detect the upper and lower bound being 49 and 12,693, respectively).tDCS may be efficacious for treatment of MDE. The data do not support the use of tDCS in treatment-resistant depression, or as an add-on augmentation treatment. Larger studies over longer treatment periods are needed." @default.
- W967575156 created "2016-06-24" @default.
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- W967575156 date "2015-10-01" @default.
- W967575156 modified "2023-10-17" @default.
- W967575156 title "Transcranial direct current stimulation (tDCS) in the treatment of depression: Systematic review and meta-analysis of efficacy and tolerability" @default.
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- W967575156 doi "https://doi.org/10.1016/j.neubiorev.2015.07.012" @default.
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