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• W96758639 abstract "Publisher Summary This chapter focuses on acute and chronic control of colonic chloride secretion by mast cell mediators. The chapter discusses those facets of immune-related intestinal secretion that are likely to be mediated, at least in part, by direct effects of mast cell mediators on the properties of the epithelium. Mast cells produce a very wide range of substances when activated by the combination of antigen with membrane-bound IgE. Among these mediators are substances that are stored in the granules and released by a process of degranulation. Mediators in this class include histamine, proteoglycans such as heparin and chondroitin sulfate, and a variety of proteolytic enzymes. Mast cells also have the capacity to synthesize mediators de novo once activated. Mast cell mediators may induce secretion at the intracellular level by a variety of mechanisms. In common with other prostaglandins, prostaglandin D2 (PGD2) is thought to act by increasing cellular levels of cAMP." @default.
• W96758639 created "2016-06-24" @default.
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• W96758639 date "1993-01-01" @default.
• W96758639 modified "2023-09-27" @default.
• W96758639 title "Acute and Chronic Control of Colonic Chloride Secretion by Mast Cell Mediators" @default.
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• W96758639 doi "https://doi.org/10.1016/b978-0-12-732085-4.50014-x" @default.
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