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• W967671062 abstract "Selective coronary angiography is the gold standard for evaluating the presence and extent of epicardial coronary artery disease. Despite advances in fluoroscopic imaging and catheterization techniques, the evaluation of the intermediate coronary stenosis (luminal diameter narrowing between 40 and 70 %) remains a challenge for invasive cardiologists secondary to multiple issues. Angiography provides only a 2D projection of the arterial lumen along the length of the vessel. Vessel characteristics (e.g., significant angulation and tortuosity) as well as limitations related to image acquisition (e.g., vessel overlap, inability to obtain a true perpendicular projection of the lesion, and the visualization of a focal short stenosis) impair the accuracy of lesion severity assessment through the traditional technique of obtaining coronary angiograms in multiple fluoroscopic views. Studies comparing coronary angiography and postmortem histopathological analysis have demonstrated the discrepancy between angiographic and actual anatomic findings [1–3]. Significant intra- and inter-observer variability is also a factor when determining the percent narrowing of a stenosis by angiography [4]. The application of quantitative coronary angiography (QCA) may minimize this discrepancy but it does not eradicate the limitations of coronary angiography. Intravascular visualization techniques such as intravascular ultrasound (IVUS) or optical coherence tomography (OCT), augment anatomical analysis but do not necessarily provide information on the functional significance of a lesion. Thus, cardiologists have focuses on physiologic assessment of a lesion to aid in management decisions. Noninvasive testing (i.e., stress testing) to determine objective evidence of ischemia is frequently conducted prior to performing coronary angiography and subsequent percutaneous coronary intervention (PCI). However, these studies not always feasible nor are the results always reliable; therefore a physiologic method of evaluating an intermediate coronary lesion while in the catheterization suite is desirable.KeywordsPercutaneous Coronary InterventionFractional Flow ReserveCoronary Flow ReserveQuantitative Coronary AngiographyCoronary Flow Velocity ReserveThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
• W967671062 created "2016-06-24" @default.
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• W967671062 date "2012-11-09" @default.
• W967671062 modified "2023-10-18" @default.
• W967671062 title "Intracoronary Hemodynamic Assessment: Coronary Flow Reserve (CFR) and Fractional Flow Reserve (FFR)" @default.
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• W967671062 doi "https://doi.org/10.1007/978-1-60761-195-0_16" @default.
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