Matches in SemOpenAlex for { <https://semopenalex.org/work/W96768767> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W96768767 endingPage "20" @default.
- W96768767 startingPage "116" @default.
- W96768767 abstract "Multiple myeloma (MM) is an incurable hematological disorder characterized by the accumulation of malignant plasma cells within the bone marrow (BM). The clinical heterogeneity of MM is dictated by the cytogenetic aberrations present in the clonal plasma cells (PCs). Cytogenetic studies in MM are hampered by the hypoproliferative nature of plasma cells in MM. Therefore, fluorescence in situ hybridization (FISH) analysis combined with magnetic-activated cell sorting (MACS) is an attractive alternative for evaluation of numerical and structural chromosomal changes in MM.Interphase FISH studies with three different specific probes for the regions containing 13q14.3(D13S319), 14q32(IGHC/IGHV) and 1q12(CEP1) were performed in 48 MM patients. Interphase FISH studies with LSI IGH/CCND1, LSI IGH/FGFR3, and LSI IGH/MAF probes were used to detect t(11;14)(q13;q32), t(4;14)(p16;q32), and t(14;16)(q32;q23) in patients with 14q32 rearrangement.Molecular cytogenetic aberrations were found in 40 (83.3%) of the 48 MM patients. 13 patients (27.1%) simultaneously had 13q deletion/monosomy 13[del(13q14)], illegitimate IGH rearrangement and chromosome 1 abnormality. Del (13q14) was detected in 21 cases (43.7%), and illegitimate IGH rearrangements in 29 (60.4%) including 6 with t (11;14) and 5 with t(4;14). None of 9 patients with illegitimate IGH rearrangements and without t(11;14) or t(4;14) we detected had t(14;16)(q32;q23). 24 of the 48 MM patients (50%) had chromosome 1 abnormalities. Among 21 patients with del (13q14), 15 patients had Amp1q12;16 had IgH rearrangements. Whereas, among 27 cases without del (13q14), 8 had Amp1q12; 13 had IgH rearrangements. There was a strong association between del(13q14) and Amp1q12 ( = 8.26, p < 0.01), and between del (13q14) and IgH rearrangement ( = 3.88, p < 0.05).13q deletion/monosomy 13, IGH rearrangement and chromosome 1 abnormality are frequent in MM. They are not randomly distributed, but strongly interconnected. Interphase FISH technique combined with MACS using CD138-specific antibody is a highly sensitive technique at detecting molecular cytogenetic aberrations in MM." @default.
- W96768767 created "2016-06-24" @default.
- W96768767 creator A5030315894 @default.
- W96768767 creator A5037507593 @default.
- W96768767 creator A5037740266 @default.
- W96768767 creator A5040485195 @default.
- W96768767 creator A5068763071 @default.
- W96768767 creator A5069528508 @default.
- W96768767 creator A5074666816 @default.
- W96768767 creator A5075511228 @default.
- W96768767 creator A5080911510 @default.
- W96768767 date "2007-06-01" @default.
- W96768767 modified "2023-09-27" @default.
- W96768767 title "Molecular cytogenetic aberrations in patients with multiple myeloma studied by interphase fluorescence in situ hybridization." @default.
- W96768767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17704743" @default.
- W96768767 hasPublicationYear "2007" @default.
- W96768767 type Work @default.
- W96768767 sameAs 96768767 @default.
- W96768767 citedByCount "10" @default.
- W96768767 countsByYear W967687672012 @default.
- W96768767 countsByYear W967687672013 @default.
- W96768767 countsByYear W967687672014 @default.
- W96768767 countsByYear W967687672015 @default.
- W96768767 countsByYear W967687672016 @default.
- W96768767 countsByYear W967687672020 @default.
- W96768767 crossrefType "journal-article" @default.
- W96768767 hasAuthorship W96768767A5030315894 @default.
- W96768767 hasAuthorship W96768767A5037507593 @default.
- W96768767 hasAuthorship W96768767A5037740266 @default.
- W96768767 hasAuthorship W96768767A5040485195 @default.
- W96768767 hasAuthorship W96768767A5068763071 @default.
- W96768767 hasAuthorship W96768767A5069528508 @default.
- W96768767 hasAuthorship W96768767A5074666816 @default.
- W96768767 hasAuthorship W96768767A5075511228 @default.
- W96768767 hasAuthorship W96768767A5080911510 @default.
- W96768767 hasConcept C104317684 @default.
- W96768767 hasConcept C142724271 @default.
- W96768767 hasConcept C153911025 @default.
- W96768767 hasConcept C174475383 @default.
- W96768767 hasConcept C193820426 @default.
- W96768767 hasConcept C203014093 @default.
- W96768767 hasConcept C2776364478 @default.
- W96768767 hasConcept C2777542201 @default.
- W96768767 hasConcept C2779142324 @default.
- W96768767 hasConcept C2780907584 @default.
- W96768767 hasConcept C29452124 @default.
- W96768767 hasConcept C30481170 @default.
- W96768767 hasConcept C53226629 @default.
- W96768767 hasConcept C54355233 @default.
- W96768767 hasConcept C71924100 @default.
- W96768767 hasConcept C86803240 @default.
- W96768767 hasConceptScore W96768767C104317684 @default.
- W96768767 hasConceptScore W96768767C142724271 @default.
- W96768767 hasConceptScore W96768767C153911025 @default.
- W96768767 hasConceptScore W96768767C174475383 @default.
- W96768767 hasConceptScore W96768767C193820426 @default.
- W96768767 hasConceptScore W96768767C203014093 @default.
- W96768767 hasConceptScore W96768767C2776364478 @default.
- W96768767 hasConceptScore W96768767C2777542201 @default.
- W96768767 hasConceptScore W96768767C2779142324 @default.
- W96768767 hasConceptScore W96768767C2780907584 @default.
- W96768767 hasConceptScore W96768767C29452124 @default.
- W96768767 hasConceptScore W96768767C30481170 @default.
- W96768767 hasConceptScore W96768767C53226629 @default.
- W96768767 hasConceptScore W96768767C54355233 @default.
- W96768767 hasConceptScore W96768767C71924100 @default.
- W96768767 hasConceptScore W96768767C86803240 @default.
- W96768767 hasIssue "2" @default.
- W96768767 hasLocation W967687671 @default.
- W96768767 hasOpenAccess W96768767 @default.
- W96768767 hasPrimaryLocation W967687671 @default.
- W96768767 hasRelatedWork W172192228 @default.
- W96768767 hasRelatedWork W1988200781 @default.
- W96768767 hasRelatedWork W1997112001 @default.
- W96768767 hasRelatedWork W2031931677 @default.
- W96768767 hasRelatedWork W2053581939 @default.
- W96768767 hasRelatedWork W2102234861 @default.
- W96768767 hasRelatedWork W2109321206 @default.
- W96768767 hasRelatedWork W2115195431 @default.
- W96768767 hasRelatedWork W2120474651 @default.
- W96768767 hasRelatedWork W2124660173 @default.
- W96768767 hasRelatedWork W2171263152 @default.
- W96768767 hasRelatedWork W2365318566 @default.
- W96768767 hasRelatedWork W2376396973 @default.
- W96768767 hasRelatedWork W2410100683 @default.
- W96768767 hasRelatedWork W2462708407 @default.
- W96768767 hasRelatedWork W2516456891 @default.
- W96768767 hasRelatedWork W2561260193 @default.
- W96768767 hasRelatedWork W2737726943 @default.
- W96768767 hasRelatedWork W3031908295 @default.
- W96768767 hasRelatedWork W53841617 @default.
- W96768767 hasVolume "29" @default.
- W96768767 isParatext "false" @default.
- W96768767 isRetracted "false" @default.
- W96768767 magId "96768767" @default.
- W96768767 workType "article" @default.