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- W9680052 abstract "1769 women studied for 4 years by the Fertility and Sterility Research Center in Mexico City received .5 mg chlormadinone acetate as a contraceptive from Day 5-25 of the cycle for a total of 28,158 cycles. 1070 endometrial biopsies were performed at different periods in the therapy for up to 52 weeks. Secretory endometrium occurred between 67.4-79.7% indicating treatment doesn't markedly interfere with endometrial glandular development. Cervical mucus, studied between Days 9 and 16 of the cycle showed physico-chemical changes preventing sperm penetration (80%) with good penetration present in 5%. Thus progestogen does not act through interference or inhibition of ovulation in the majority. Side effects included breakthrough bleeding (20% in cycles 1-6; 10% by cycle 9), headache 14.4% (control 1-12%) and bloating of lower abdomen (11%). .5mg chlormadinone acetate has proven toleration for up to 4 years." @default.
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- W9680052 date "1968-01-01" @default.
- W9680052 modified "2023-10-18" @default.
- W9680052 title "Continuous low dose progestagen for contraception." @default.
- W9680052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12155573" @default.
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