FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W968197862> ?p ?o ?g. }

• W968197862 endingPage "561" @default.
• W968197862 startingPage "552" @default.
• W968197862 abstract "The underlying pharmacokinetic profile of liposomal drug delivery systems is not yet fully known. This is primarily due to a lack of suitable quantitative bioanalytical methodology to simultaneously determine separate liposomal-encapsulated and non-encapsulated drug tissue concentrations in complex biological samples. Here, an LC–MS method was developed which enables the simultaneous quantification of separate liposomal-encapsulated prednisolone phosphate and non-encapsulated prednisolone concentrations in whole blood and liver tissue. Liquid chromatography, negative electrospray ionization and Orbitrap-MS analysis allowed highly accurate and sensitive detection of prednisolone phosphate (PP) and prednisolone (P) in complex matrix. Using dexamethasone phosphate and dexamethasone as internal standards, the quantitative LC–MS method was optimized and validated for high selectivity, sensitivity and quantitative accuracy of PP and P from liposomes. The lower limits of quantitation were 0.99 μmol/L blood and 0.53 nmol/g liver for PP, and 229 nmol/L blood and 0.514 nmol/g liver for P. Quantitative accuracies of 84–118% were observed. The intra-run precision was ≤11%. Application of this new LC–MS method will yield the first liposomal pharmacokinetic profile showing accurate encapsulated and non-encapsulated drug tissue concentrations separately. This is also the first quantitative LC–MS method for the simultaneous quantification of the prodrug PP and its parent drug P in whole blood and liver tissue samples." @default.
• W968197862 created "2016-06-24" @default.
• W968197862 creator A5015824696 @default.
• W968197862 creator A5015863265 @default.
• W968197862 creator A5021816839 @default.
• W968197862 creator A5035111870 @default.
• W968197862 creator A5044320547 @default.
• W968197862 creator A5047764464 @default.
• W968197862 creator A5050602150 @default.
• W968197862 date "2015-11-01" @default.
• W968197862 modified "2023-09-27" @default.
• W968197862 title "Quantitative LC–MS determination of liposomal encapsulated prednisolone phosphate and non-encapsulated prednisolone concentrations in murine whole blood and liver tissue" @default.
• W968197862 cites W1710962414 @default.
• W968197862 cites W1971363581 @default.
• W968197862 cites W1993289303 @default.
• W968197862 cites W1995478520 @default.
• W968197862 cites W1998192458 @default.
• W968197862 cites W1998346656 @default.
• W968197862 cites W2010222138 @default.
• W968197862 cites W2011736406 @default.
• W968197862 cites W2014590342 @default.
• W968197862 cites W2017459399 @default.
• W968197862 cites W2021998662 @default.
• W968197862 cites W2022145767 @default.
• W968197862 cites W2029206161 @default.
• W968197862 cites W2034878330 @default.
• W968197862 cites W2040982724 @default.
• W968197862 cites W2043609830 @default.
• W968197862 cites W2045493500 @default.
• W968197862 cites W2046391461 @default.
• W968197862 cites W2048914079 @default.
• W968197862 cites W2051649033 @default.
• W968197862 cites W2063838991 @default.
• W968197862 cites W2066459637 @default.
• W968197862 cites W2071540896 @default.
• W968197862 cites W2074544404 @default.
• W968197862 cites W2076226743 @default.
• W968197862 cites W2081725263 @default.
• W968197862 cites W2093662286 @default.
• W968197862 cites W2115913205 @default.
• W968197862 cites W2117216132 @default.
• W968197862 cites W2130558079 @default.
• W968197862 cites W2134601695 @default.
• W968197862 cites W2135726947 @default.
• W968197862 cites W2136226205 @default.
• W968197862 cites W2142959883 @default.
• W968197862 cites W2152400777 @default.
• W968197862 cites W25749702 @default.
• W968197862 doi "https://doi.org/10.1016/j.jpba.2015.07.012" @default.
• W968197862 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26319748" @default.
• W968197862 hasPublicationYear "2015" @default.
• W968197862 type Work @default.
• W968197862 sameAs 968197862 @default.
• W968197862 citedByCount "7" @default.
• W968197862 countsByYear W9681978622018 @default.
• W968197862 countsByYear W9681978622019 @default.
• W968197862 countsByYear W9681978622020 @default.
• W968197862 countsByYear W9681978622021 @default.
• W968197862 countsByYear W9681978622022 @default.
• W968197862 crossrefType "journal-article" @default.
• W968197862 hasAuthorship W968197862A5015824696 @default.
• W968197862 hasAuthorship W968197862A5015863265 @default.
• W968197862 hasAuthorship W968197862A5021816839 @default.
• W968197862 hasAuthorship W968197862A5035111870 @default.
• W968197862 hasAuthorship W968197862A5044320547 @default.
• W968197862 hasAuthorship W968197862A5047764464 @default.
• W968197862 hasAuthorship W968197862A5050602150 @default.
• W968197862 hasConcept C108215921 @default.
• W968197862 hasConcept C112705442 @default.
• W968197862 hasConcept C126322002 @default.
• W968197862 hasConcept C137535248 @default.
• W968197862 hasConcept C185154212 @default.
• W968197862 hasConcept C185592680 @default.
• W968197862 hasConcept C2776715498 @default.
• W968197862 hasConcept C43617362 @default.
• W968197862 hasConcept C55493867 @default.
• W968197862 hasConcept C71924100 @default.
• W968197862 hasConcept C95986675 @default.
• W968197862 hasConcept C98274493 @default.
• W968197862 hasConceptScore W968197862C108215921 @default.
• W968197862 hasConceptScore W968197862C112705442 @default.
• W968197862 hasConceptScore W968197862C126322002 @default.
• W968197862 hasConceptScore W968197862C137535248 @default.
• W968197862 hasConceptScore W968197862C185154212 @default.
• W968197862 hasConceptScore W968197862C185592680 @default.
• W968197862 hasConceptScore W968197862C2776715498 @default.
• W968197862 hasConceptScore W968197862C43617362 @default.
• W968197862 hasConceptScore W968197862C55493867 @default.
• W968197862 hasConceptScore W968197862C71924100 @default.
• W968197862 hasConceptScore W968197862C95986675 @default.
• W968197862 hasConceptScore W968197862C98274493 @default.
• W968197862 hasLocation W9681978621 @default.
• W968197862 hasLocation W9681978622 @default.
• W968197862 hasOpenAccess W968197862 @default.
• W968197862 hasPrimaryLocation W9681978621 @default.
• W968197862 hasRelatedWork W1971236148 @default.
• W968197862 hasRelatedWork W2029938981 @default.
• W968197862 hasRelatedWork W2059353851 @default.

• next