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• W968319610 abstract "Uterine Leiomyomas (UL) are common mesenchymal benign tumors that represent a significant public health problem. The deregulation of growth factors and microRNAs (miRNAs), shortening of telomeres, excessive production of disorganized extracellular matrix, loss of heterozygosity and recurrent chromosomal aberrations (including 7q22 deletion and chromosomal rearrangements in 12q15) have been suggested to contribute to the growth of UL. A significant number of tumors presented mutations of MED12The aims of this study were: to investigate MED12 mutation; to evaluate the expression levels of HMGA2 and their miRNAs predicted (let-7a, miR-26a, miR-26b); the expression of miRNAs mapped at 7q22 (miR-25, miR-93, and miR106b) and the expression levels of BRCA1, FANCA and their predictive miRNAs. Eight-five fresh frozen UL and 34 adjacent normal myometrium (MM) were obtained from 54 patients who had undergone a hysterectomy procedure. Quantitative real time RT-PCR was applied to evaluate the expression levels of miRs (miR-let7a, miR-25, miR-93, miR106b, miR-21, miR-26a, miR-26b, miR-197 and miR-143) using RNU44, RNU48 and U47 as endogenous control and to evaluate the expression of HMGA2, BRCA1 and FANCA using RPLP0 and GUSB as endogenous control. We detected 50% (42/85) of samples with MED12 mutation. A significant overexpression (p<0,001) of HMGA2 was detected in UL compared with MM, including samples with the presence of MED12 mutation. These data indicated that overexpression of HMGA2 may coexist with MED12 mutation. The miRNAs predicted to regulate HMGA2 were found significantly downregulated: let-7a (p<0,001), miR-26a (p<0,001), miR-26b (p<0,001). The negative correlation verified between HMGA2 and their predicted miRNAs support the evidence of interaction between them. The miRNAs mapped at 7q22 (miR-25, miR-93, and miR106b) were found as downregulated (p=0.016; p=0.003; p<0,001, respectively) in about 50% of samples. The previous study revealed genomic loss involving 7q22 in 15% of UL. Therefore, other mechanisms than deletion in 7q22 can lead to miRNAs downexpression in LU. BRCA1 and FANCA overexpression were detected in UL in comparison with MM (p<0,001 e p<0,001, respectively) suggesting the involvement of these genes in UL." @default.
• W968319610 created "2016-06-24" @default.
• W968319610 creator A5065736278 @default.
• W968319610 date "2013-04-30" @default.
• W968319610 modified "2023-09-23" @default.
• W968319610 title "CARACTERIZAÇÃO DE MUTAÇÕES NO GENE MED12, DOS miRNAS MAPEADOS EM 7q22 E DOS CANDIDATOS A REGULAÇÃO DO GENE HMGA2 EM LEIOMIOMAS UTERINOS" @default.
• W968319610 cites W1577577364 @default.
• W968319610 cites W1591832885 @default.
• W968319610 cites W1648301895 @default.
• W968319610 cites W17469937 @default.
• W968319610 cites W1967527609 @default.
• W968319610 cites W1968470609 @default.
• W968319610 cites W1969018878 @default.
• W968319610 cites W1969023674 @default.
• W968319610 cites W1972848579 @default.
• W968319610 cites W1973308914 @default.
• W968319610 cites W1976044138 @default.
• W968319610 cites W1978802594 @default.
• W968319610 cites W1984930347 @default.
• W968319610 cites W1985221365 @default.
• W968319610 cites W1987231873 @default.
• W968319610 cites W1987511993 @default.
• W968319610 cites W1987622202 @default.
• W968319610 cites W1988805499 @default.
• W968319610 cites W1989224324 @default.
• W968319610 cites W1989336885 @default.
• W968319610 cites W1995907211 @default.
• W968319610 cites W2000693350 @default.
• W968319610 cites W2001810755 @default.
• W968319610 cites W2002239473 @default.
• W968319610 cites W2006655793 @default.
• W968319610 cites W2006797972 @default.
• W968319610 cites W2008247501 @default.
• W968319610 cites W2008389846 @default.
• W968319610 cites W2011123928 @default.
• W968319610 cites W2011446505 @default.
• W968319610 cites W2013356100 @default.
• W968319610 cites W2013546250 @default.
• W968319610 cites W2014929974 @default.
• W968319610 cites W2014994159 @default.
• W968319610 cites W2015110625 @default.
• W968319610 cites W2016683192 @default.
• W968319610 cites W2017303715 @default.
• W968319610 cites W2022184922 @default.
• W968319610 cites W2022425782 @default.
• W968319610 cites W2025035284 @default.
• W968319610 cites W2025112578 @default.
• W968319610 cites W2025635760 @default.
• W968319610 cites W2026448022 @default.
• W968319610 cites W2032118557 @default.
• W968319610 cites W2035213975 @default.
• W968319610 cites W2035361790 @default.
• W968319610 cites W2037589121 @default.
• W968319610 cites W2038743660 @default.
• W968319610 cites W2041617605 @default.
• W968319610 cites W2044967196 @default.
• W968319610 cites W2048835818 @default.
• W968319610 cites W2050683533 @default.
• W968319610 cites W2056550498 @default.
• W968319610 cites W2058174458 @default.
• W968319610 cites W2059442967 @default.
• W968319610 cites W2059866734 @default.
• W968319610 cites W2060818805 @default.
• W968319610 cites W2062575747 @default.
• W968319610 cites W2063224639 @default.
• W968319610 cites W2066868410 @default.
• W968319610 cites W2067473451 @default.
• W968319610 cites W2068249243 @default.
• W968319610 cites W2071504168 @default.
• W968319610 cites W2072108247 @default.
• W968319610 cites W2072269334 @default.
• W968319610 cites W2072626324 @default.
• W968319610 cites W2077177773 @default.
• W968319610 cites W2078444067 @default.
• W968319610 cites W207870397 @default.
• W968319610 cites W2081036514 @default.
• W968319610 cites W2088023073 @default.
• W968319610 cites W2088403484 @default.
• W968319610 cites W2093612217 @default.
• W968319610 cites W2094097897 @default.
• W968319610 cites W2096573862 @default.
• W968319610 cites W2098534922 @default.
• W968319610 cites W2101293029 @default.
• W968319610 cites W2104146201 @default.
• W968319610 cites W2104898895 @default.
• W968319610 cites W2106670703 @default.
• W968319610 cites W2107277218 @default.
• W968319610 cites W2108118664 @default.
• W968319610 cites W2110177672 @default.
• W968319610 cites W2110181729 @default.
• W968319610 cites W2114133506 @default.
• W968319610 cites W2115069206 @default.
• W968319610 cites W2117381929 @default.
• W968319610 cites W2119962483 @default.
• W968319610 cites W2120775052 @default.
• W968319610 cites W2122211092 @default.
• W968319610 cites W2122935349 @default.
• W968319610 cites W2123168045 @default.
• W968319610 cites W2125336329 @default.
• W968319610 cites W2128055323 @default.

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