FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W968476618> ?p ?o ?g. }

• W968476618 abstract "Organic synthesis has a rich history, ever since Friedrich Wohler’s synthesis of urea from ammonium cyanate in 1828 that gave birth to this important discipline of science. While organic synthesis has found many application and witnessed many triumphs in improving the quality of life, it is the creative instinct, reminiscent of art, associated with this discipline that holds special appeal. This creative flair finds its best expression in the domain of natural product synthesis, which has witnessed spectacular advances and attainments, particularly in the second half of the 20th century . Many natural products exhibit wide range of biological activities and thus provide useful leads for drug discovery. But very often, they are available only in minute quantities from natural sources and access to them poses threat to biodiversity conservation. Therefore, it is sometimes necessary to synthesize bioactive natural products to obtain requisite quantities and build diversity around their scaffold to explore their therapeutic potential. Thus, natural product synthesis provides an opportunity to organic chemists not only to demonstrate their creativity and intellectual ability but also render available materials for possible application in human health and wellbeing. It is not surprising that the study of the chemistry, biology and synthesis of natural products has emerged as one of the most flourishing and rewarding frontiers in modern science. The efforts delineated in this thesis are the continuation of our research group’s long standing interest directed towards the total synthesis of structurally complex and biologically promising natural products. The present thesis entitled “Towards the total synthesis of polycyclic polyprenylated acyl phloroglucin (PPAP) natural products : garsubellin A and hyperforin” is organized in two parts. PART A : Towards the total synthesis of garsubellin A and PART B : Towards the total synthesis of hyperforin. PART A : TOWARDS THE TOTAL SYNTHESIS OF GARSUBELLIN A Part A deals with the studies towards the total synthesis of garsubellin A 1, a polycyclic polyprenylated acyl phloroglucin (PPAP) natural product. In the year 1997, garsubellin A was isolated from the wood of garcinia subelliptica by Fukuyama and coworkers. Structurally, garsubellin A belongs to a small but rapidly growing class of natural products characterized by the presence of a highly oxygenated and densely functionalized bicyclo[3.3.1]nonan-2,4,9-trione core embellished with more than one hydrophobic prenyl side chain. Apart from its enchanting structural architecture, garsubellin A 1 also exhibits promising biological activity. Neurodegenerative diseases like Alzheimer’s have been attributed to the deficiencies in the level of neurotransmitter acetylcholine (ACh). Any inducer of the enzyme choline acetyltransferase (ChAT), which is responsible for the biosynthesis of acetylcholine has therapeutic potential in the area of neuro degeneration. Preliminary investigations have indicated that 1 enhances in vitro choline…" @default.
• W968476618 created "2016-06-24" @default.
• W968476618 creator A5061187538 @default.
• W968476618 date "2008-05-01" @default.
• W968476618 modified "2023-09-23" @default.
• W968476618 title "Towards The Total Synthesis Of Polycyclic Polyprenylated Acyl Phloroglucin (PPAP) Natural Products : Garsubellin A And Hyperforin" @default.
• W968476618 hasPublicationYear "2008" @default.
• W968476618 type Work @default.
• W968476618 sameAs 968476618 @default.
• W968476618 citedByCount "0" @default.
• W968476618 crossrefType "journal-article" @default.
• W968476618 hasAuthorship W968476618A5061187538 @default.
• W968476618 hasConcept C138885662 @default.
• W968476618 hasConcept C151730666 @default.
• W968476618 hasConcept C178790620 @default.
• W968476618 hasConcept C185592680 @default.
• W968476618 hasConcept C2776608160 @default.
• W968476618 hasConcept C2779396153 @default.
• W968476618 hasConcept C35753019 @default.
• W968476618 hasConcept C86803240 @default.
• W968476618 hasConcept C95124753 @default.
• W968476618 hasConceptScore W968476618C138885662 @default.
• W968476618 hasConceptScore W968476618C151730666 @default.
• W968476618 hasConceptScore W968476618C178790620 @default.
• W968476618 hasConceptScore W968476618C185592680 @default.
• W968476618 hasConceptScore W968476618C2776608160 @default.
• W968476618 hasConceptScore W968476618C2779396153 @default.
• W968476618 hasConceptScore W968476618C35753019 @default.
• W968476618 hasConceptScore W968476618C86803240 @default.
• W968476618 hasConceptScore W968476618C95124753 @default.
• W968476618 hasLocation W9684766181 @default.
• W968476618 hasOpenAccess W968476618 @default.
• W968476618 hasPrimaryLocation W9684766181 @default.
• W968476618 hasRelatedWork W1638593214 @default.
• W968476618 hasRelatedWork W1994454883 @default.
• W968476618 hasRelatedWork W2010870472 @default.
• W968476618 hasRelatedWork W2027414216 @default.
• W968476618 hasRelatedWork W2122461411 @default.
• W968476618 hasRelatedWork W2309888152 @default.
• W968476618 hasRelatedWork W2611005388 @default.
• W968476618 hasRelatedWork W2773954679 @default.
• W968476618 hasRelatedWork W2901270794 @default.
• W968476618 hasRelatedWork W2949263019 @default.
• W968476618 hasRelatedWork W2950268737 @default.
• W968476618 hasRelatedWork W2951967628 @default.
• W968476618 hasRelatedWork W2952254948 @default.
• W968476618 hasRelatedWork W2953326841 @default.
• W968476618 hasRelatedWork W297631536 @default.
• W968476618 hasRelatedWork W3130135265 @default.
• W968476618 hasRelatedWork W313364422 @default.
• W968476618 hasRelatedWork W3175932012 @default.
• W968476618 hasRelatedWork W3193685462 @default.
• W968476618 hasRelatedWork W996618533 @default.
• W968476618 isParatext "false" @default.
• W968476618 isRetracted "false" @default.
• W968476618 magId "968476618" @default.
• W968476618 workType "article" @default.