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- W968972531 abstract "Recently, studies are carried out on the mode of action of antidepressants at the molecular level and new pharmacological methods to identify or to further distinguish between antidepressant agents. In an in vitro study, employing crude synaptosomal preparations from various rat brain regions, relevance of the Dopamine (DA) uptake in the mechanism of action of various antidepressants is examined. None of the numerous antidepressant drugs and other biogenic mine uptake blocking agents examined exhibited selective DA uptake inhibition. It is pointed out that it is difficult to ascribe the antidepressant effect to inhibit the uptake of a particular biogenic amine. In the area of new models for the detection of antidepressant activity of drugs, the potential use of the bulbectomized rat is further studied in this chapter. Bilateral ablation of the olfactory bulbs of rats resulted in diverse behavioral changes and most of these are reversed by chronic pre-treatment with antidepressant drugs. The mode of action at the molecular level of the antidepressant drugs continues to be explored with regard to determining the basis for the discrepancy between the time-course of the bio-chemical and pharmacological responses that are observed within minutes or hours, and their clinical antidepressant action that require administration of the drugs for weeks to attain clinical efficacy. The therapeutic action of tricyclic antidepressants may be related to postsynaptic adaptive changes in the sensitivity of the nor-adrenergic adenylate cyclase receptor system rather than to acute presynaptic events." @default.
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- W968972531 date "1978-01-01" @default.
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- W968972531 title "Chapter 1. Antidepressants" @default.
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- W968972531 doi "https://doi.org/10.1016/s0065-7743(08)60604-1" @default.
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