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• W968989757 abstract "The mechanism of immune suppression in a severely stressful condition is not known. Since the demonstration of β-endorphin receptor on the surface of the circulating lymphocyte, it was reported that β-endorphin could suppress PHA stimulated lymphoblastogenesis. Because the concentration of β-endorphin was supraphysiologically high, it is doubtful that β-endorphin can suppress the lymphoblastogenesis directly in vivo. We investigated the suppression of PHA stimulated lymphoblastogenesis by β-endorphin in vitro and the effect of β-endorphin in some conditions where β-endorphin increases in vivo.PHA induced lymphoblastogenesis of T lymphocyte was maximal at the concentration of 5 μg/ml. β-endorphin could not suppress the blastogenesis even at the highest concentration. In the five healthy men who received metyrapone the previous night, PHA stimulated blastogeneses were not significantly suppressed. In a patient with Nelson’s syndrome, the lymphoblastogenesis was suppressed at all concentrations of PHA.Cortisol significant suppressed the blastogenesis even at the concentration of 10 μg/dl and its suppressive effect was shown in dose dependant manner.Our results suggested that β-endorphin could not suppress the lymphoblastogenesis directly in vivo." @default.
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• W968989757 date "1986-01-31" @default.
• W968989757 modified "2023-10-11" @default.
• W968989757 title "Effect of β-endorphin and Cortisol on the PHA Stimulated Lymphoblastogenesis" @default.
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• W968989757 doi "https://doi.org/10.3904/kjim.1986.1.1.98" @default.
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