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- W969218221 abstract "This chapter summarizes properties and regulations, which indicate that the cAMP-phosphodiesterases (PDEs) play an important role in cAMP signaling as well as acting as integrators of multiple signaling pathways. Although much needs to be done to fully understand their functions, these PDEs should be regarded as homeostatic regulators of signaling. The second messenger cAMP generated by adenylyl cyclases either interacts with and activates intracellular effectors or is degraded and inactivated by phosphodiesterases (PDEs). Of the eleven PDE families thus far identified, three families of isoenzymes are specific for cAMP, including family 4,7, and 8. Given their high affinity for cAMP in the submicromolar to micro-molar range, they are the primary enzymes involved in the inactivation of this cyclic nucleotide under resting or stimulated conditions, thus playing a critical role in signaling." @default.
- W969218221 created "2016-06-24" @default.
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- W969218221 date "2003-01-01" @default.
- W969218221 modified "2023-10-16" @default.
- W969218221 title "The cAMP-Specific Phosphodiesterases: A Class of Diverse Enzymes That Defines the Properties and Compartmentalization of the cAMP Signal" @default.
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- W969218221 doi "https://doi.org/10.1016/b978-012124546-7/50554-4" @default.
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