Matches in SemOpenAlex for { <https://semopenalex.org/work/W969414235> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W969414235 endingPage "666" @default.
- W969414235 startingPage "663" @default.
- W969414235 abstract "Background: The relationship between mitochondrial DNA and tumor has become a hot spot of study recently. Mutations in mitochondria have been found in many malignant tumors or precancerous lesions. Aims: To investigate the mitochondrial DNA D-loop region mutation in tissues of colorectal cancer, and to appraise its role in the pathogenesis and development of colorectal cancer. Methods: Mitochondrial DNA D-loop region of tumor tissue and paracancerous tissue in 40 patients with colorectal cancer were patients with colorectal cancer were amplified by polymerase chain reaction (PCR), and the products were sequenced directly. Results: In 40 cases of colorectal cancer, 50 polymorphisms in D-loop region were found, among which 2 were new polymorphisms that have not been recorded in BLAST database. Mutations of mitochondrial DNA D-loop region were identified in 14 patients (35%) with 12 mutational sites, including 9 point mutations, 2 microsatellite instabilities and 1 deletion. Conclusions: There is a high frequency of polymorphism and mutation in mitochondrial DNA D-loop region in colorectal cancer, and it may play an important role in the pathogenesis and development of colorectal cancer." @default.
- W969414235 created "2016-06-24" @default.
- W969414235 creator A5001109590 @default.
- W969414235 creator A5002276376 @default.
- W969414235 creator A5005085280 @default.
- W969414235 creator A5032714786 @default.
- W969414235 creator A5033897817 @default.
- W969414235 creator A5042306271 @default.
- W969414235 creator A5082909438 @default.
- W969414235 creator A5091756509 @default.
- W969414235 date "2008-11-25" @default.
- W969414235 modified "2023-09-24" @default.
- W969414235 title "结直肠癌组织中线粒体DNA D-环区突变的研究" @default.
- W969414235 hasPublicationYear "2008" @default.
- W969414235 type Work @default.
- W969414235 sameAs 969414235 @default.
- W969414235 citedByCount "0" @default.
- W969414235 crossrefType "journal-article" @default.
- W969414235 hasAuthorship W969414235A5001109590 @default.
- W969414235 hasAuthorship W969414235A5002276376 @default.
- W969414235 hasAuthorship W969414235A5005085280 @default.
- W969414235 hasAuthorship W969414235A5032714786 @default.
- W969414235 hasAuthorship W969414235A5033897817 @default.
- W969414235 hasAuthorship W969414235A5042306271 @default.
- W969414235 hasAuthorship W969414235A5082909438 @default.
- W969414235 hasAuthorship W969414235A5091756509 @default.
- W969414235 hasConcept C104317684 @default.
- W969414235 hasConcept C121608353 @default.
- W969414235 hasConcept C153911025 @default.
- W969414235 hasConcept C176944494 @default.
- W969414235 hasConcept C180754005 @default.
- W969414235 hasConcept C198268994 @default.
- W969414235 hasConcept C203014093 @default.
- W969414235 hasConcept C24586158 @default.
- W969414235 hasConcept C2779767149 @default.
- W969414235 hasConcept C2780942790 @default.
- W969414235 hasConcept C49105822 @default.
- W969414235 hasConcept C501734568 @default.
- W969414235 hasConcept C502942594 @default.
- W969414235 hasConcept C526805850 @default.
- W969414235 hasConcept C54355233 @default.
- W969414235 hasConcept C552990157 @default.
- W969414235 hasConcept C61320498 @default.
- W969414235 hasConcept C86803240 @default.
- W969414235 hasConceptScore W969414235C104317684 @default.
- W969414235 hasConceptScore W969414235C121608353 @default.
- W969414235 hasConceptScore W969414235C153911025 @default.
- W969414235 hasConceptScore W969414235C176944494 @default.
- W969414235 hasConceptScore W969414235C180754005 @default.
- W969414235 hasConceptScore W969414235C198268994 @default.
- W969414235 hasConceptScore W969414235C203014093 @default.
- W969414235 hasConceptScore W969414235C24586158 @default.
- W969414235 hasConceptScore W969414235C2779767149 @default.
- W969414235 hasConceptScore W969414235C2780942790 @default.
- W969414235 hasConceptScore W969414235C49105822 @default.
- W969414235 hasConceptScore W969414235C501734568 @default.
- W969414235 hasConceptScore W969414235C502942594 @default.
- W969414235 hasConceptScore W969414235C526805850 @default.
- W969414235 hasConceptScore W969414235C54355233 @default.
- W969414235 hasConceptScore W969414235C552990157 @default.
- W969414235 hasConceptScore W969414235C61320498 @default.
- W969414235 hasConceptScore W969414235C86803240 @default.
- W969414235 hasIssue "11" @default.
- W969414235 hasLocation W9694142351 @default.
- W969414235 hasOpenAccess W969414235 @default.
- W969414235 hasPrimaryLocation W9694142351 @default.
- W969414235 hasVolume "13" @default.
- W969414235 isParatext "false" @default.
- W969414235 isRetracted "false" @default.
- W969414235 magId "969414235" @default.
- W969414235 workType "article" @default.