Matches in SemOpenAlex for { <https://semopenalex.org/work/W969523895> ?p ?o ?g. }
- W969523895 endingPage "661" @default.
- W969523895 startingPage "621" @default.
- W969523895 abstract "There is growing evidence that oxidative stress (OS) may play an important role in the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). Cells normally have a number of mechanisms to resist against damage induced by cellular free radicals during OS. The major antioxidant defenses consist of antioxidant scavengers such as glutathione (GSH), vitamin C (ascorbic acid), vitamin E (α-tocopherol), carotenoids, polyphenols, flavonoids, and antioxidant enzymes. This chapter focuses on the actions of in vitro application of natural nutritional antioxidants in experimental models of neurodegenerative disorders. The capability of these compounds to counteract the damaging effects of reactive oxygen species (ROS) and the relevance of this biochemical effect in their putative neuroprotective action are examined in the chapter. Among the numerous biochemical effects of ROS and antioxidants, particular emphasis is given to their interference with the transcriptional factor NF-κB function, whose role in the pathophysiology of neurodegenerative disorders is gaining increasing attention. The chapter reviews the effects of the administration of pharmacological doses of nutritional antioxidants in animal models and in patients with AD, PD, and ALS. A detailed analysis of the role of dietary intake of polyphenols and other antioxidant vitamins in the prevention of AD and PD is discussed in the chapter." @default.
- W969523895 created "2016-06-24" @default.
- W969523895 creator A5030733407 @default.
- W969523895 creator A5046342727 @default.
- W969523895 creator A5079852388 @default.
- W969523895 creator A5089668241 @default.
- W969523895 date "2007-01-01" @default.
- W969523895 modified "2023-09-26" @default.
- W969523895 title "Prevention and Therapy of Neurodegenerative Disorders: Role of Nutritional Antioxidants" @default.
- W969523895 cites W1023155169 @default.
- W969523895 cites W1261198562 @default.
- W969523895 cites W1481697456 @default.
- W969523895 cites W1483563853 @default.
- W969523895 cites W1488872763 @default.
- W969523895 cites W1490128449 @default.
- W969523895 cites W1504584187 @default.
- W969523895 cites W1507112934 @default.
- W969523895 cites W1515578871 @default.
- W969523895 cites W1519463750 @default.
- W969523895 cites W1530276807 @default.
- W969523895 cites W1536161802 @default.
- W969523895 cites W1537390295 @default.
- W969523895 cites W1540436551 @default.
- W969523895 cites W1542061701 @default.
- W969523895 cites W1542152284 @default.
- W969523895 cites W1560505179 @default.
- W969523895 cites W1564588342 @default.
- W969523895 cites W1568529372 @default.
- W969523895 cites W1571319136 @default.
- W969523895 cites W1571764227 @default.
- W969523895 cites W1574544450 @default.
- W969523895 cites W1575495254 @default.
- W969523895 cites W1577403013 @default.
- W969523895 cites W1590514634 @default.
- W969523895 cites W1593725384 @default.
- W969523895 cites W1611341694 @default.
- W969523895 cites W1621509181 @default.
- W969523895 cites W166102277 @default.
- W969523895 cites W1662308449 @default.
- W969523895 cites W1718709781 @default.
- W969523895 cites W1796430339 @default.
- W969523895 cites W1807257653 @default.
- W969523895 cites W1820596764 @default.
- W969523895 cites W1826275188 @default.
- W969523895 cites W1872376120 @default.
- W969523895 cites W1877873625 @default.
- W969523895 cites W1888783223 @default.
- W969523895 cites W1914622032 @default.
- W969523895 cites W1929245453 @default.
- W969523895 cites W1934800228 @default.
- W969523895 cites W1940344336 @default.
- W969523895 cites W1957382934 @default.
- W969523895 cites W1960735897 @default.
- W969523895 cites W1963917943 @default.
- W969523895 cites W1964747384 @default.
- W969523895 cites W1964780858 @default.
- W969523895 cites W1966791814 @default.
- W969523895 cites W1968537977 @default.
- W969523895 cites W1968786165 @default.
- W969523895 cites W1969257616 @default.
- W969523895 cites W1969280474 @default.
- W969523895 cites W1969800514 @default.
- W969523895 cites W1970603050 @default.
- W969523895 cites W1970921883 @default.
- W969523895 cites W1971032331 @default.
- W969523895 cites W1972555872 @default.
- W969523895 cites W1974380679 @default.
- W969523895 cites W1975481676 @default.
- W969523895 cites W1977069725 @default.
- W969523895 cites W1977406521 @default.
- W969523895 cites W1977817124 @default.
- W969523895 cites W1978688182 @default.
- W969523895 cites W1978701238 @default.
- W969523895 cites W1978874104 @default.
- W969523895 cites W1979496463 @default.
- W969523895 cites W1980160486 @default.
- W969523895 cites W1980825813 @default.
- W969523895 cites W1980855715 @default.
- W969523895 cites W1981166064 @default.
- W969523895 cites W1981354055 @default.
- W969523895 cites W1981513372 @default.
- W969523895 cites W1982070131 @default.
- W969523895 cites W1983493663 @default.
- W969523895 cites W1983668432 @default.
- W969523895 cites W1984940419 @default.
- W969523895 cites W1985613988 @default.
- W969523895 cites W1985904485 @default.
- W969523895 cites W1987510933 @default.
- W969523895 cites W1989530212 @default.
- W969523895 cites W1991084221 @default.
- W969523895 cites W1991511436 @default.
- W969523895 cites W1991743392 @default.
- W969523895 cites W1993250284 @default.
- W969523895 cites W1993266132 @default.
- W969523895 cites W1993336124 @default.
- W969523895 cites W1995379683 @default.
- W969523895 cites W1995505431 @default.
- W969523895 cites W1996175319 @default.