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- W96952592 abstract "Publisher Summary The complexity of the respiratory tract makes the elucidation of the carcinogenic processes in the respiratory organ a great challenge. A major complication in identifying airborne agents that are carcinogenic is the high background level of lung cancer and other respiratory tract cancers caused by cigarette smoking. This is evident from the controversy surrounding estimates of lung cancers for residential exposure to the well-established carcinogens, radon, and its progency. The vast majority of lung cancer cases estimated to be attributable to radon occur in smokers. There is a high degree of uncertainty associated with the lung cancer risk estimates for nonsmokers. These same difficulties extend to assessing the cancer hazards of other air pollutants based on epidemiological observations. For new materials proposed for introduction to commence, increased attention must be given to proactive approaches to identifying potential carcinogens through laboratory animal and in vitro assays and structure-activity evaluations. The identification of such compounds early in development provides the opportunity to select alternative compounds that do not pose a carcinogenic hazard or to design engineering controls to limit human exposures." @default.
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- W96952592 date "1999-01-01" @default.
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- W96952592 title "Carcinogenic Responses to Air Pollutants" @default.
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