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- W969652224 abstract "Stimulation encoding strategy is one of the most essential electrophysiological issues among the many issues for retinal prosthesis development. To optimize the electrical stimuli applied through retinal prosthesis, understanding retinal network in normal and degenerate retina is necessary. Therefore, we explored the retinal network using multielectrode array (MEA) in normal and rd1 mice. Rd1 mouse is a well-established animal model for retinitis pigmentosa (RP), a major retinal disease leading to blindness in adult. In rd1 mice, ~10 Hz oscillatory rhythm (slow wave component) was identified in spontaneous retinal activity and we proposed the stronger glutamatergic input from bipolar cell to retinal ganglion cell be the main contributor for this rhythm. With electrical stimulus, normal and degenerate retina responded differently, and the threshold charge density for stimulation was significantly higher in rd1 mouse retina." @default.
- W969652224 created "2016-06-24" @default.
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- W969652224 date "2009-01-01" @default.
- W969652224 modified "2023-09-26" @default.
- W969652224 title "Exploring Retinal Network with Multielectrode Array for Retinal Prosthesis" @default.
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- W969652224 doi "https://doi.org/10.1007/978-3-642-03891-4_31" @default.
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