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- W96978698 abstract "The metabolism of brain tissue shows some characteristic and specific features (for details and further references, see MCILWAIN [1966], BACHELARD and MCILWAIN [1969], BALACZ [1970]). Thus the organ is active continuously, and in spite of its small weight it is responsible for about 20% of the resting oxygen consumption of the body. Further, although isolated brain tissues can oxidize a variety of substrates in vitro, only glucose can normally pass the blood-brain barrier with sufficient speed to maintain the energy requirements in vivo. Measurements of arteriovenous differences for glucose, oxygen, and carbon dioxide show that the respiratory quotient is close to unity, thus confirming that glucose is the sole substrate. These measurements show that about 95% of the glucose consumed is oxidized to carbon dioxide. The rest of the glucose (about 5%) appears as an arteriovenous difference for lactate (see COHEN [1971]). However, the arteriovenous balance does not reveal the rapid interconversion of glucose carbon between the tricarboxylic acid cycle and the glutamate group of amino acids. In fact, as much as 30% of the 14C administered in radioactive glucose may label these acids (aspartate, glutamate, glutamine, and λ aminobutyrate), but since an equivalent amount of amino acid carbon is fed into the Krebs cycle the end result is compatible with simple glucose oxidation (ROBERTS et al. [1959], VRBA [1962], see also TOWER [1960], BACHELARD [1965]). The rapid turnover of the glutamate group of amino acids, which is partly specific for the brain, may be related to the fact that some of the acids function as excitatory or inhibitory transmitters." @default.
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- W96978698 date "1974-01-01" @default.
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- W96978698 title "Acid-Base and Energy Metabolism of the Brain in Hypercapnia and Hypocapnia" @default.
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- W96978698 doi "https://doi.org/10.1007/978-1-4612-9831-1_23" @default.
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