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- W970003197 endingPage "540" @default.
- W970003197 startingPage "517" @default.
- W970003197 abstract "Dialysis-related amyloidosis (DRA) is a clinical syndrome of pain, loss of function and other symptoms due to the deposition of amyloid consisting of β2-microglobulin (β2m) in the musculoskeletal system. The condition is seen in patients who suffer from chronic kidney disease and are treated with hemodialysis for a long time. Even though β2m easily can be manipulated to form amyloid in laboratory experiments under non-physiological conditions the precise mechanisms involved in the formation of β2m-amyloid in patients with DRA have been difficult to unravel. The current knowledge which is reviewed here indicates that conformational fluctuations centered around the D-strand, the DE-loop, and around the cis-configured Pro32 peptide bond are involved in β2m amyloidosis. Also required are highly increased concentrations of circulating β2m and possibly various post-translational modifications mediated by the pro-inflammatory environment in uremic blood, together with the influence of divalent metal ions (specifically Cu2 +), uremic toxins, and dialysis-enhanced redox-processes. It seems plausible that domain-swapped β2m dimers act as building blocks of β-spine cross-β -sheet fibrils consisting of otherwise globular, roughly natively folded protein. An activated complement system and cellular activation perpetuate these reactions which due to the affinity of β2m-amyloid for the collagen of synovial surfaces result in the DRA syndrome." @default.
- W970003197 created "2016-06-24" @default.
- W970003197 creator A5033697331 @default.
- W970003197 creator A5041571684 @default.
- W970003197 date "2012-01-01" @default.
- W970003197 modified "2023-09-30" @default.
- W970003197 title "β2-Microglobulin Amyloidosis" @default.
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