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- W970254458 abstract "目的 探讨谷胱甘肽S-转移酶（GST）M1、T1基因多态与散发性大肠腺癌（SCRAC）遗传易感性的关联。方法 应用多重聚合酶链反应（PCR）技术，对经病理组织学确诊的104例SCRAC患者及同期在本院体检的无血缘关系的101例健康人，检测其GSTM1和GSTT1基因多态性。结果 （1）在健康人和SCRAC患者，GSTM1、GSTT1空白基因型的频率差异均无显著性（前者46.5％:56.7％,χ2=2.13,P＞0.05；后者47.5％:60.6％,χ2=3.52,P＞0.05）。（2）GSTM1空白基因型频率在近端与远端SCRAC患者间、在老年与非老年SCRAC间的频率差异均无显著性；而GSTT1空白基因型的频率差异有显著性（前者44.4％:66.2％,χ2=3.97,P＜0.05；后者70.9％:49.0％,χ2=5.21,P＜0.05）。（3）GSTM1、GSTT1均为空白基因联合型的个体患SCRAC的危险性升高4.33倍（9.6％:26.9％,χ2=7.89,ν=3,P＜0.05）。结论 单独的GSTM1或GSTT1空白基因型与SCRAC遗传易感性无关，但GSTT1空白基因型与远端SCRAC遗传易感性有关，且多见于老年患者。GSTM1、GSTT1均为空白基因的联合基因型是SCRAC的易感基因型。" @default.
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- W970254458 date "2002-08-20" @default.
- W970254458 modified "2023-09-25" @default.
- W970254458 title "谷胱甘肽S-转移酶M1、T1基因多态与散发性大肠腺癌遗传易感性" @default.
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